Buspirone MedChemExpress (MCE)

Product Name	Buspirone
Synonyms	Buspirone BUPROPIONHCL BUSPIRONE,USP 5)decane-7,9-dione,8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-8-azaspiro( 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE 8-(4-(4-(2-pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione Synonyms Buspirone BUPROPIONHCL BUSPIRONE,USP 5)decane-7,9-dione,8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-8-azaspiro( 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE 8-(4-(4-(2-pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE HYDROCHLORIDE
CAS	36505-84-7
EINECS	253-072-2
Chemical Formula	C21H31N5O2
Molecular Weight	385.50314
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Buspirone Buspirone MedChemExpress (MCE) HY-B1115A 36505-84-7 99.86% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Buspirone Buspirone MedChemExpress (MCE) HY-B1115A 36505-84-7 99.86% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research. The anxiolytic and anti-depressant effects of Buspirone are produced by activating 5-HT1A autoreceptors and 5-HT1A heteroreceptors, respectively[1]. Buspirone (0-400 µg/mL 6 hours) has cytotoxic effect in lymphocytes[2]. Buspirone (0-180 µg/mL 0-3 hours lymphocytes) induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[2]. Buspirone (1-5 mg/kg i.p. and i.g. for 5 days C57BL/6N mice) reduces anxiety/depression behaviors[1]. Buspirone (1-5 mg/kg i.p. and i.g. for 5 days C57BL/6N mice) restores immobilization stress (IS)-shifted β-diversity in the gut microbiota[1]. 5-HT1A Receptor Dopamine D2 receptor \| \| \| \| \| \| \| \| \| \| [1]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17 11(1):6094. [Content Brief] [2]. Salimi A, et, al. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Curr Clin Pharmacol. 2018 13(2):120-127. [Content Brief]
Supplier Website	https://www.medchemexpress.com/buspirone.html
Last Update	2025-05-21 16:50:25

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