W1400 MedChemExpress (MCE)

Product Name	1400W
Synonyms	400W 1400W W 1400 1400W DIHYDROCHLORIDE N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE Synonyms 400W 1400W W 1400 1400W DIHYDROCHLORIDE N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE
CAS	180001-34-7
EINECS
Chemical Formula	C10H15N3
Molecular Weight	177.25
inchi
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Descriptions	1400W 1400W MedChemExpress (MCE) HY-18730 180001-34-7 W1400 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions 1400W 1400W MedChemExpress (MCE) HY-18730 180001-34-7 W1400 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation. 1400W (60 μM, 1 h) reduces NO, 3-NT and MDA production in primary adult microglia, and prevents neuronal cell apoptosis in cerebral cortex[2]. 1400W (0.1-10 mg/kg, s.c., once time) inhibits the leakage of rats ileum, with an EC50 of 0.16 mg/kg[1]. Ki: 2 µM (nNOS), 50 µM (eNOS)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21 272(8):4959-63. [Content Brief] [2]. Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15 319:188-199. [Content Brief]
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Last Update	2025-05-21 16:50:25

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