Hesperadin MedChemExpress (MCE)

Product Name	Hesperadin
Synonyms	Hesperadin HESPERADIN Hesperadine Hesperadin hydrochloride Hesperadin Hesperadine (Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide Synonyms Hesperadin HESPERADIN Hesperadine Hesperadin hydrochloride Hesperadin Hesperadine (Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide N-[(3Z)-2-Oxo-3-[phenyl-[4-(piperidin-1-ylMethyl)anilino]Methylidene]-1H-indol-5-yl]ethanesulfonaMide N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide Hesperadin
CAS	422513-13-1
EINECS	200-258-5
Chemical Formula	C29H32N4O3S
Molecular Weight	516.65
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Get quote
Descriptions	Hesperadin Hesperadin MedChemExpress (MCE) HY-12054 422513-13-1 98.00% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Hesperadin Hesperadin MedChemExpress (MCE) HY-12054 422513-13-1 98.00% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral. Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50 of 40 nM[1]. Hesperadin (0.01-10 μM 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1]. Hesperadin (100-200 nM 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1]. Hesperadin (20 mg/kg/d i.v.) prolongs the survival of xenograft mice via synergistic effect with temozolomide (TMZ)[2]. Trypanosoma Aurora B 250 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Neal J, et, al. The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms. Mol Microbiol. 2009 Apr 72(2): 442-58. [Content Brief] [2]. Wahafu A, et, al. Targeting Aurora kinase B attenuates chemoresistance in glioblastoma via a synergistic manner with temozolomide. Pathol Res Pract. 2019 Nov 215(11): 152617. [Content Brief] [3]. Hu Y, et, al. Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral. Int J Mol Sci. 2017 Sep 8 18(9):1929. [Content Brief]
Last Update	2025-04-01 14:45:47

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