MF63 MedChemExpress (MCE)

Product Name	MF63
Synonyms	MF63 MF-63 MF 63 MF-63 CS-2773 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic 2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile Synonyms MF63 MF-63 MF 63 MF-63 CS-2773 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic 2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile 1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)- 2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile
CAS	892549-43-8
EINECS
Chemical Formula	C23H11ClN4
Molecular Weight	378.81
inchi
Package	10 mM * 1 mL;5 mg;10 mg
Price	Get quote
Descriptions	MF63 MF63 MedChemExpress (MCE) HY-13283 892549-43-8 99.55% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions MF63 MF63 MedChemExpress (MCE) HY-13283 892549-43-8 99.55% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE2, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1. MF63 (0.01-100 µM 24 h) selectively inhibits PGE2 induced by 10 ng/mL IL-1β in A549 cells, and increases the formation of PGF2α in a dose-dependent manner[1]. MF63 (10 µM 24 h) enhances the expression of various metallothionein 1 (MT1) subtypes and endogenous antagonists of IL-1 and IL-36 with the anti-inflammatory effects[2]. MF63 (100 mg/kg p.o. single dose) attenuates PEG2 accumulation in air pouches and brains of the KI (knock-in mPGES-1 gene) mice and inhibits PEG2 formation in a dose-dependent manner[1]. MF63 (10 mg/kg and 100 mg/kg p.o. single dose) inhibits the hyperalgesic response induced by LPS in the KI mice, with dose-dependently manner[1]. MF63 (0-150 mg/kg p.o. single dose) inhibits PEG2 synthesis, hyperalgesia, pyresis and relieves Chronic Osteoarthritic-Like Pain in the guinea pig[1]. MF63 (0-100 mg/kg p.o. twice daily for 4 days) has gastrointestinal tolerability in KI mice and nonhuman primates[1]. mPGES-1[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Xu D, et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep 326(3):754-63. [Content Brief] [2]. Tuure L, et al. Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes. Br J Pharmacol. 2020 Sep 177(18):4134-4146.
Last Update	2025-04-01 14:45:47

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