AAE581 MedChemExpress (MCE)

Product Name	Balicatib
Synonyms	AAE581 AAE-581 AAE 581 AAE-581 BALICATIB Balicatib Balicatib, AAE-581 Synonyms AAE581 AAE-581 AAE 581 AAE-581 BALICATIB Balicatib Balicatib, AAE-581 N-(1-(CYANOMETHYLCARBAMOYL)CYCLOHEXYL)-4-(4-PROPYLPIPERAZIN-1-YL)BENZAMIDE N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide Balicatib(AAE-581) Balicatib N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide
CAS	354813-19-7
EINECS	200-256-5
Chemical Formula	C23H33N5O2
Molecular Weight	411.54
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Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
Price	Get quote
Descriptions	Balicatib Balicatib MedChemExpress (MCE) HY-15100 354813-19-7 AAE581 98.00% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Balicatib Balicatib MedChemExpress (MCE) HY-15100 354813-19-7 AAE581 98.00% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Balicatib (AAE581) is a potent, orally active and selective cathepsin K inhibitor with IC50 values of 22, 61, 48, 2900 nM for cathepsin K, cathepsin B, cathepsin L, cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis. Balicatib (0-10 µM) shows less than 1.5-fold accumulation of Type I collagen at concentrations up to 10 µM in human dermal fibroblasts[2]. Balicatib (0, 3, 10, 50 mg/kg Oral gavage twice daily for 18 months) partially prevented ovariectomyinduced changes in bone mass, inhibited bone turnover at most sites, and had an stimulatory effect on periosteal bone formation in cynomolgus monkeys[1]. cathepsin K 22 nM (IC50) cathepsin L 48 nM (IC50) Cathepsin B 61 nM (IC50) cathepsin S 2900 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Jerome C, et al. Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int. 2012 Jan 23(1):339-49. [Content Brief] [2]. Gauthier JY, et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1 18(3):923-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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