SCE-2787 MedChemExpress (MCE)

Product Name	Cefozopran
Synonyms	SCE2787 Firstci sce2787 SCE-1787 SCE 2787 CEFOZOPRAN Cefozopran Synonyms SCE2787 Firstci sce2787 SCE-1787 SCE 2787 CEFOZOPRAN Cefozopran Cefozopran main-ring Cefozopran(SCE 2787) 1-[[(6R,7R)-7-[[2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium Inner Salt (6R,7R)-7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino}-3-(1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 1-{[(6R,7R)-7-{[(2E)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino}-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1H-imidazo[1,2-b]pyridazin-4-ium chloride 1-[[(6R,7R)-7-[[(2Z)-(5-Amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-imidazo[1,2-b]pyridazinium hydroxide inner salt 1-[[(6r,7r)-7-[[(2z)-(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-imidazo[1,2-b]pyridazinium hydroxide inner salt
CAS	113359-04-9
EINECS	601-249-3
Chemical Formula	C19H17N9O5S2
Molecular Weight	515.52
inchi	InChI=1/C19H17N9O5S2.ClH/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27 /h2-6,12,17H,7-8H2,1H3,(H3-,20,22,23,25,29,31,32) 1H/b24-11+ inchi InChI=1/C19H17N9O5S2.ClH/c1-33-24-11(14-23-19(20)35-25-14)15(29)22-12-16(30)28-13(18(31)32)9(8-34-17(12)28)7-26-5-6-27-10(26)3-2-4-21-27 /h2-6,12,17H,7-8H2,1H3,(H3-,20,22,23,25,29,31,32) 1H/b24-11+ /t12-,17- /m1./s1
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Descriptions	Cefozopran Cefozopran MedChemExpress (MCE) HY-B0771 113359-04-9 SCE-2787 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Cefozopran Cefozopran MedChemExpress (MCE) HY-B0771 113359-04-9 SCE-2787 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Cefozopran (SCE-2787) is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms. Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and P. aeruginosa, which are refractory to other cephalosporins[2]. Cefozopran (SCE-2787) (5-80 mg/kg s.c. twice a day for 5 days four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg s.c. twice a day for 7 days five-week-old CBA/J female mice) is as effective as Ceftazidime[2]. β-lactam \| \| \| \| \| \| \| \| \| \| [1]. Sato T, et al. A prospective, randomized study comparing cefozopran with piperacillin-tazobactam plus ceftazidime as empirical therapy for febrile neutropenia in children with hematological disorders. Pediatr Blood Cancer. 2008 51(6):774-777. [Content Brief] [2]. Iizawa Y, et al. Therapeutic effect of cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice. Antimicrob Agents Chemother. 1993 37(1):100-105. [Content Brief]
Last Update	2025-04-01 14:45:47

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