Chlorcyclizine MedChemExpress (MCE)

Product Name	CHLORCYCLIZINE HYDROCHLORIDE
Synonyms	eramide di-paralene CHLORCYCLIZINE HCL Ah-289 hydrochloride chlorcycliziniumchloride CHLORCYCLIZINE HYDROCHLORIDE Chlorocyclizine hydrochloride Synonyms eramide di-paralene CHLORCYCLIZINE HCL Ah-289 hydrochloride chlorcycliziniumchloride CHLORCYCLIZINE HYDROCHLORIDE Chlorocyclizine hydrochloride 1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine 1-(p-chlorobenzhydryl)-4-methylpiperazinehydrochloride 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-piperazinhydrochloride 1-(p-chloro-alpha-phenylbenzyl)-4-methylpiperazinehydrochloride 1-[(4-CHLOROPHENYL)PHENYL-METHYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
CAS	14362-31-3
EINECS	238-335-1
Chemical Formula	C18H22Cl2N2
Molecular Weight	337.29
inchi	InChI=1/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
Package	10 mM * 1 mL;100 mg;200 mg;500 mg
Price	Get quote
Descriptions	Chlorcyclizine hydrochloride Chlorcyclizine hydrochloride MedChemExpress (MCE) HY-112067A 14362-31-3 99.77% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Chlorcyclizine hydrochloride Chlorcyclizine hydrochloride MedChemExpress (MCE) HY-112067A 14362-31-3 99.77% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Chlorcyclizine hydrochloride is a histamine H1 antagonist. Pregnant rats administered 30, 60, and 90mg/kg Chlorcyclizine during the sensitive period for palate development survived until scheduled sacrifice on Gestation Days (GDs) 17 or 21. The rats administered 60 or 90mg/kg Chlorcyclizine have transient adverse clinical signs (chromorhinorrhea, red peri-oral substance, urogenital staining, and scant stool) and a concomitant body weight loss of 7% and 11%, respectively, over the dosing interval. Rats administered 30mg/kg Chlorcyclizine do not exhibit any adverse clinical signs, but do not gain weight over the dose interval as would be expected during pregnancy. Based on the testing facility’s historical control database (16 studies, n=380). pregnant rats typically gain about 6% body weight from GDs 12 to 15[1]. Rats[1] Timed-mated CRL:CD [SD] female rats between 9 and 13 weeks of age at initiation of dosing and weighing between 245 and 363 g are used. Rats are administered a single daily oral gavage dose of 30, 60, or 90 mg/kg Chlorcyclizine (n=8/group) during the sensitive period for palate development, GDs 11 to 14. These doses are selected such that 30 mg/kg is a likely no-effect dose and higher doses of 60 and/or 90 mg/kg will induce a moderate or high incidence of fetal cleft palate. Given that CRL:CDs [SD] rats have an extremely low incidence of spontaneous cleft palate in the testing laboratory, as well as to avoid unnecessary use of animals, a methylcellulose control group is omitted[1]. Histamine H1[1] In Vivo Pregnant rats administered 30, 60, and 90mg/kg Chlorcyclizine during the sensitive period for palate development survived until scheduled sacrifice on Gestation Days (GDs) 17 or 21. The rats administered 60 or 90mg/kg Chlorcyclizine have transient adverse clinical signs (chromorhinorrhea, red peri-oral substance, urogenital staining, and scant stool) and a concomitant body weight loss of 7% and 11%, respectively, over the dosing interval. Rats administered 30mg/kg Chlorcyclizine do not exhibit any adverse clinical signs, but do not gain weight over the dose interval as would be expected during pregnancy. Based on the testing facility’s historical control database (16 studies, n=380). pregnant rats typically gain about 6% body weight from GDs 12 to 15[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. \| \| \| \| \| \| \| \| \| \| [1]. Enright BP, et al. Effects of the histamine H1 antagonist Chlorcyclizine on rat fetal palate development. Birth Defects Res B Dev Reprod Toxicol. 2010 Dec 89(6):474-84. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Chlorcyclizine_hydrochloride.html
Last Update	2025-05-21 16:50:25

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