UNC926 MedChemExpress (MCE)

Product Name	UNC-926 Hydrochloride
Synonyms	UNC926 UNC 926 UNC-926 UNC-926 Hydochloride UNC-926 Hydrochloride (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone (3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone Synonyms UNC926 UNC 926 UNC-926 UNC-926 Hydochloride UNC-926 Hydrochloride (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone (3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone Methanone, (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]- (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
CAS	1184136-10-4
EINECS
Chemical Formula	C16H21BrN2O
Molecular Weight	337.25
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Get quote
Descriptions	UNC926 UNC926 MedChemExpress (MCE) HY-16510 1184136-10-4 99.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions UNC926 UNC926 MedChemExpress (MCE) HY-16510 1184136-10-4 99.82% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. UNC926 is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM. UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1]. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1]. IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1] In Vitro UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1]. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UNC926 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Herold JM, et al. Structure–activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012 3(45):45–51.
Last Update	2025-04-01 14:45:47

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