PPTN MedChemExpress (MCE)

Product Name	PPTN (free base)
Synonyms	PPTN (free base);2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-
CAS	1160271-30-6
EINECS
Chemical Formula	C29H24F3NO2
Molecular Weight	475.5
inchi
Package	1 mg;5 mg;10 mg;25 mg
Price	Get quote
Descriptions	PPTN PPTN MedChemExpress (MCE) HY-110322A 1160271-30-6 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions PPTN PPTN MedChemExpress (MCE) HY-110322A 1160271-30-6 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity. PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors[1]. PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1]. PPTN (10 µM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38[2]. KB: 434 pM (P2Y14 receptor)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul 84(1):41-9. [Content Brief] [2]. Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec 131:104567. [Content Brief]
Supplier Website	https://www.medchemexpress.com/pptn.html
Last Update	2025-05-21 16:50:25

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