Buclizine MedChemExpress (MCE)

Product Name	BUCLIZINE
Synonyms	Postafen BUCLIZINE Histabutizine HHitabutyzyne Histabuticine Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)- piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl) Synonyms Postafen BUCLIZINE Histabutizine HHitabutyzyne Histabuticine Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)- piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl) Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
CAS	82-95-1
EINECS	201-448-1
Chemical Formula	C28H33ClN2
Molecular Weight	433.03
inchi
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Descriptions	Buclizine Buclizine MedChemExpress (MCE) HY-A0128 82-95-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Buclizine Buclizine MedChemExpress (MCE) HY-A0128 82-95-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Buclizine is an orally active antihistamine antiallergic compound. Buclizine is a potent teratogen in the rat and shows anti-tumor activity. Buclizine (0.1-100 μM 72 h) inhibits growth of MCF-7 cells[2]. Buclizine (9.625-77 μM 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner[2]. Buclizine (0-75 μM 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression[2]. Buclizine dihydrochloride (30-200 mg/kg tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat[3]. \| \| \| \| \| \| \| \| \| \| [1]. Gamal A E Mostafa, et al. Buclizine. Profiles Drug Subst Excip Relat Methodol. 2011 36:1-33. [Content Brief] [2]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget. 2016 Mar 29 7(13):16818-39. [Content Brief] [3]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1 95(1):109-11. [Content Brief]
Last Update	2025-04-01 14:45:47

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