Fenazoxine MedChemExpress (MCE)

Product Name	3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
Synonyms	NEFOPAM fenazoxine NEFOPAMI HCL Nefopam HCL CP2000 Nefopanhydrochloride 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-5-benzoxazocine 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-2,5-benzoxazocine Synonyms NEFOPAM fenazoxine NEFOPAMI HCL Nefopam HCL CP2000 Nefopanhydrochloride 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-5-benzoxazocine 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-2,5-benzoxazocine 3-methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
CAS	13669-70-0
EINECS	237-148-2
Chemical Formula	C17H19NO
Molecular Weight	253.34
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Descriptions	Nefopam Nefopam MedChemExpress (MCE) HY-133195 13669-70-0 Fenazoxine Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Nefopam Nefopam MedChemExpress (MCE) HY-133195 13669-70-0 Fenazoxine Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups. Nefopam (0.1-100 μM 15 min) inhibits the uptake of 22Na in a concentration-dependent manner in SK-N-SH cells[1]. Nefopam (0-10 mg/kg i.v. single) protects mice against electroshock induced seizures[1]. Nefopam (10, 30, 60 mg/kg i.p. single) shows a dose-dependent attenuation of mechanical allodynia and decreased neurokinin-1 receptor concentration in vincristine-induced peripheral neuropathy model[2]. \| \| \| \| \| \| \| \| \| \| [1]. Verleye M, et al. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004 Jul 9 1013(2):249-55. [Content Brief] [2]. Lee JY, et al. The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice. J Pain Res. 2020 Feb 7 13:323-329. [Content Brief] [3]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr 27(2):103-11. [Content Brief]
Last Update	2025-04-01 14:45:47

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