SB 243213 MedChemExpress (MCE)

Product Name	SB 243213 dihydrochloride
Synonyms	SB 243213 dihydrochloride
CAS	1780372-25-9
EINECS
Chemical Formula	C22H20ClF3N4O2
Molecular Weight	464.87
inchi
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Descriptions	SB 243213 dihydrochloride SB 243213 dihydrochloride MedChemExpress (MCE) HY-103112A 1780372-25-9 99.0% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions SB 243213 dihydrochloride SB 243213 dihydrochloride MedChemExpress (MCE) HY-103112A 1780372-25-9 99.0% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders. SB 243213 dihydrochloride shows little affinity (pKi1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows weak affinity (pKi1D and D3 receptors and moderate affinity (pKi=6.7) for the cloned human D2 receptor[1]. SB 243213 dihydrochloride shows 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels[1]. SB 243213 dihydrochloride (0.1-10 mg/kg p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box[1]. SB 243213 dihydrochloride (0.3 mg/kg p.o. 1 h pre-test) significantly increases time spent in social interaction[1]. Human 5-HT2C Receptor 9.37 (pKi) human 5-HT1A Receptor human 5-HT1B Receptor 5.5 (pKi) human 5-HT1D Receptor 6.32 (pKi) human 5-HT1E Receptor human 5-HT1F Receptor 5.35 (pKi) Human 5-HT2A Receptor 7.01 (pKi) human 5-HT2B Receptor 7.2 (pKi) Human 5-HT6 Receptor 6.5 (pKi) Human 5-HT7 Receptor 5.64 (pKi) \| \| \| \| \| \| \| \| \| \| [1]. Wood MD, et al. SB-243213 a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology. 2001 Aug 41(2):186-99. [Content Brief]
Supplier Website	https://www.medchemexpress.com/sb-243213-dihydrochloride.html
Last Update	2025-05-21 16:50:25

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