DBCO-NHCO-PEG4-amine MedChemExpress (MCE)

Product Name	DBCO-PEG4-NH2
Synonyms	DBCO-PEG4-NH2 DBCO-PEG4-amine DBCO-NHCOPEG4-amine DBCO-NH-PEG4-CH2CH2NH2 DBCO-NHCO-PEG4-amine TFA salt Azadibenzocyclooctyne-PEG4-amine DBCO-PEG4 amine(ADIBO-PEG4-amine) Synonyms DBCO-PEG4-NH2 DBCO-PEG4-amine DBCO-NHCOPEG4-amine DBCO-NH-PEG4-CH2CH2NH2 DBCO-NHCO-PEG4-amine TFA salt Azadibenzocyclooctyne-PEG4-amine DBCO-PEG4 amine(ADIBO-PEG4-amine) 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide
CAS	1255942-08-5
EINECS
Chemical Formula	C29H37N3O6
Molecular Weight	523.62
inchi
Package	Inquiry
Price	Get quote
Descriptions	DBCO-NHCO-PEG4-amine DBCO-NHCO-PEG4-amine MedChemExpress (MCE) HY-124386 1255942-08-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions DBCO-NHCO-PEG4-amine DBCO-NHCO-PEG4-amine MedChemExpress (MCE) HY-124386 1255942-08-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively). PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. Cleavable Linker PEGs \| \| \| \| \| \| \| \| \| \| [1]. Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7 15(5):2054-2059. . [Content Brief]
Last Update	2025-04-01 14:45:47

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