KP363 MedChemExpress (MCE)

Product Name	Butenafine
Synonyms	BUTENAFINE Butenafine 4-tert-Butylbenzylmethyl 1-naphtylmethylamine (4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine Synonyms BUTENAFINE Butenafine 4-tert-Butylbenzylmethyl 1-naphtylmethylamine (4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
CAS	101828-21-1
EINECS
Chemical Formula	C23H27N
Molecular Weight	317.47
inchi	InChI=1/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3
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Descriptions	Butenafine Butenafine MedChemExpress (MCE) HY-114518 101828-21-1 KP363 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Butenafine Butenafine MedChemExpress (MCE) HY-114518 101828-21-1 KP363 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent. Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as tinea pedis, tinea cruris, tinea versicolor. Butenafine demonstrates comparable activity against the dermatophytes with a MIC range of 0.03-0.25 μg/ml. It displays limited activity against the yeast Candida albicans and no activity against Malassezia furfur[1].Butenafine (25 50 or 100 μM) eliminates the promastigote forms of L. amazonensis and L. braziliensis in a dose-dependent manner, and shows EC50 values of 34.10±3.76 μM and 81.25±10.24 μM, respectively, in peritoneal macrophages from BALB/c mice. Butenafine induces mild cytotoxicity in peritoneal macrophages from BALB/c mice with a CC50 of 97.88 μM[1]. Butenafine (subcutaneous administration 1-100 mg/kg) to mice has no effect on the central and autonomic nervous systems. Topical administration of 0.3-3.0% butenafine solutions to guinea pigs also has no effect on the somatic nervous system[1].In primary therapeutic studies on guinea pigs, Butenafine (1% topical application 4-10 days day 3 and 4 post-infection) exhibits a complete cure after 10 days in vivo-effect on dermatophytosis, T. mentagrophytes[1].Butenafine (0.125, 0.25, 0.5 and 1.0% topical application q.d. or b.i.d. for 10 days day 4 post-infection) exhibits a 100% cure after 0.5% or 1% application and has no difference in efficacy between 1% q.d. and b.i.d. in vivo-effect on dermatophytosis, T. mentagrophytes[1]. IC50: antifungal[1] In Vitro Butenafine demonstrates comparable activity against the dermatophytes with a MIC range of 0.03-0.25 μg/ml. It displays limited activity against the yeast Candida albicans and no activity against Malassezia furfur[1].Butenafine (25 50 or 100 μM) eliminates the promastigote forms of L. amazonensis and L. braziliensis in a dose-dependent manner, and shows EC50 values of 34.10±3.76 μM and 81.25±10.24 μM, respectively, in peritoneal macrophages from BALB/c mice. Butenafine induces mild cytotoxicity in peritoneal macrophages from BALB/c mice with a CC50 of 97.88 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Butenafine Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Katrina Kokjohn, et al. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria.Int J Dermatol. 2003 Sep 42 Suppl 1:11-7. [Content Brief] [2]. Adriana Bezerra-Souza, et al. The antifungal compound butenafine eliminates promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis. 2016 Dec 65(6 Pt A):702-707. [Content Brief] [3]. Topical Antifungal Agent. Butenafine
Last Update	2025-04-01 14:45:47

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