FNDR-20123 MedChemExpress (MCE)

Product Name	Benzamide, N-hydroxy-4-[[4-[4-(1-pyrrolidinylmethyl)phenyl]-1H-1,2,3-triazol-1-yl]methyl]-
Synonyms	N-hydroxy-4-((4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide;Benzamide, N-hydroxy-4-[[4-[4-(1-pyrrolidinylmethyl)phenyl]-1H-1,2,3-triazol-1-yl]methyl]-
CAS	1267502-34-0
EINECS
Chemical Formula	C21H23N5O2
Molecular Weight	377.44
inchi
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Descriptions	FNDR-20123 free base FNDR-20123 free base MedChemExpress (MCE) HY-131708 1267502-34-0 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions FNDR-20123 free base FNDR-20123 free base MedChemExpress (MCE) HY-131708 1267502-34-0 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations. FNDR-20123 is active against all resistant strains tested so far, which will be highly valuable in eliminating the rapidly evolving drug-resistant parasite[1]. FNDR-20123 (10-50 mg/kg p.o. bw for 4 days) is also able to reduce parasitaemia significantly in a mouse model for P. falciparum infection[1]. human HDAC 3 nM (IC50) Plasmodium HDAC 31 nM (IC50) HDAC1 25 nM (IC50) HDAC2 29 nM (IC50) HDAC3 2 nM (IC50) HDAC6 11 nM (IC50) HDAC8 282 nM (IC50) Plasmodium \| \| \| \| \| \| \| \| \| \| [1]. Potluri V, et al. Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria. Malar J. 2020 19(1):365. Published 2020 Oct 12. [Content Brief]
Last Update	2025-04-01 14:45:47

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