Fluphenazine MedChemExpress (MCE)

Product Name	FLUPHENAZINE
Synonyms	FLUPHENAZINE moditen(tablorelixir) 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- 1-piperazineethanol,4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl) Synonyms FLUPHENAZINE moditen(tablorelixir) 10-(3-(2-Hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- 1-piperazineethanol,4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl) 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine 1-Piperazineethanol, 4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]- 2-(4-(3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
CAS	69-23-8
EINECS	200-702-9
Chemical Formula	C22H26F3N3OS
Molecular Weight	437.52
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Descriptions	Fluphenazine Fluphenazine MedChemExpress (MCE) HY-119980 69-23-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Fluphenazine Fluphenazine MedChemExpress (MCE) HY-119980 69-23-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2. Fluphenazine (1 mg/kg IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5]. Fluphenazine (0.125-1 mg/kg IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing inhibits significantly climbing behaviour[6]. Dopamine receptor, Sodium channels, SARS-CoV-2[1][2] In Vivo Fluphenazine (1 mg/kg IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5]. Fluphenazine (0.125-1 mg/kg IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing inhibits significantly climbing behaviour[6]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice (injected with 60 mg/kg Methylphenidate)[6] \| \| \| \| \| \| \| \| \| \| [1]. Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006 1106(1):72-81. [Content Brief] [2]. Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec 25(10):1123-1140. [Content Brief] [3]. Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing 2022 Jan. [Content Brief] [4]. Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21 238(21):2291-2. [Content Brief] [5]. Abdel-Hamid HA, et al. Teratogenic effect of diphenylhydantoin and/or fluphenazine in mice. J Appl Toxicol. 1996 May-Jun 16(3):221-5. [Content Brief] [6]. Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul 312(3):225-7. [Content Brief]
Last Update	2025-04-01 14:45:47

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