SKF 101468 MedChemExpress (MCE)

Product Name	Ropinirole
Synonyms	Ropinirole SKF-101468 ROPINIROLE 91374-21-9 4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-on 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Synonyms Ropinirole SKF-101468 ROPINIROLE 91374-21-9 4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-on 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one 2H-indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-
CAS	91374-21-9
EINECS
Chemical Formula	C16H24N2O
Molecular Weight	260.37
inchi	InChI=1/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
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Descriptions	Ropinirole Ropinirole MedChemExpress (MCE) HY-B0623 91374-21-9 SKF 101468 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Ropinirole Ropinirole MedChemExpress (MCE) HY-B0623 91374-21-9 SKF 101468 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease. Ropinirole has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2]. Ropinirole (0.1-10 mg/kg i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2]. D2 Receptor 29 nM (Ki) hD2 Receptor 7.4 (pEC50) hD3 Receptor 8.4 (pEC50) hD4.4 Receptor 6.8 (pEC50) \| \| \| \| \| \| \| \| \| \| [1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [Content Brief] [2]. Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec 17(12):1981-93. [Content Brief]
Last Update	2025-04-01 14:45:47

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