KAD-1229 free acid anhydrous; S21403 free acid anhydrous MedChemExpress (MCE)

Product Name	Mitiglinide
Synonyms	Mitiglinide MITIGLINIDE Unii-D86I0xlb13 Mitiglinide [inn] Mitiglinide Impurity Ⅱ 2-benzyl-4-(octahydro-2H-isoindol-2-yl)-4-oxobutanoic acid [2(S)-cis]-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic acid Synonyms Mitiglinide MITIGLINIDE Unii-D86I0xlb13 Mitiglinide [inn] Mitiglinide Impurity Ⅱ 2-benzyl-4-(octahydro-2H-isoindol-2-yl)-4-oxobutanoic acid [2(S)-cis]-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic acid (2S)-4-[(3aR,7aS)-octahydro-1H-isoindol-2-yl]-2-benzyl-4-oxobutanoic acid (2S)-2-benzyl-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxobutanoic acid 2H-Isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, (αS,3aR,7aS)- [2(S)-cis]-Octahydro-gamma-oxo-alpha-(phenylmethyl)-2H-isoindole-2-butanoic acid [2(s)-cis]-octahydro-gamma-oxo-alpha-(phenylmethyl)-2h-isoindole-2-butanoic acid
CAS	145375-43-5
EINECS	1312995-182-4
Chemical Formula	C19H25NO3
Molecular Weight	315.41
inchi	InChI=1/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)
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Descriptions	Mitiglinide Mitiglinide MedChemExpress (MCE) HY-B0682 145375-43-5 KAD-1229 free acid anhydrous Descriptions Mitiglinide Mitiglinide MedChemExpress (MCE) HY-B0682 145375-43-5 KAD-1229 free acid anhydrous S21403 free acid anhydrous Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Mitiglinide (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide can be used for the research of type 2 diabetes. Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1]. Mitiglinide (1-3 mg/kg p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2]. KATP channel[1] In Vitro Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Mitiglinide Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Y Sunaga, et al. The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol. 2001 Nov 9 431(1):119-25. [Content Brief] [2]. Kiyoshi Ichikawa, et al. Effect of KAD-1229, a novel hypoglycaemic agent, on plasma glucose levels after meal load in type 2 diabetic rats. Clin Exp Pharmacol Physiol. May-Jun 2002 29(5-6):423-7. [Content Brief]
Last Update	2025-04-01 14:45:47

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