Amlodipine MedChemExpress (MCE)

Product Name	Amlodipine mesylate
Synonyms	Amlodipine mesylate 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate Synonyms Amlodipine mesylate 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-di 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid
CAS	246852-12-0
EINECS
Chemical Formula	C20H25ClN2O5.CH4O3S
Molecular Weight	504.99
inchi
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Descriptions	Amlodipine mesylate Amlodipine mesylate MedChemExpress (MCE) HY-B0317C 246852-12-0 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Amlodipine mesylate Amlodipine mesylate MedChemExpress (MCE) HY-B0317C 246852-12-0 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer. Amlodipine mesylate (20-40 μM 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively[3]. Amlodipine mesylate (30 μM pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells[3]. Amlodipine mesylate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells[3]. Amlodipine mesylate (5 mg/kg/day s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4]. Amlodipine mesylate (10 mg/kg i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3]. L-type calcium channel \| \| \| \| \| \| \| \| \| \| [1]. Kishen G. Bulsara, et al. Amlodipine. [2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov 50(5):896]. Drugs. 1995 50(3):560-586. [Content Brief] [3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25 492(2-3):103-12. [Content Brief] [4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb 41(2):80-87. [Content Brief]
Last Update	2025-04-01 14:45:47

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