HSR803 free base MedChemExpress (MCE)

Product Name	Itopride
Synonyms	ITOPRIDE Itopride 122898-67-3 3,4-Dimethoxy-N-[4-[2-(dimethylamino)ethoxy]benzyl]benzamide N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide n-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxy-benzamide Synonyms ITOPRIDE Itopride 122898-67-3 3,4-Dimethoxy-N-[4-[2-(dimethylamino)ethoxy]benzyl]benzamide N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide n-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxy-benzamide N-[[4-(2-dimethylaminoethyloxy)phenyl]methyl]-3,4-dimethoxybenzamide N-[[4-(2-dimethylaminoethyloxy)phenyl]methyl]-3,4-dimethoxy-benzamide N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzene-1-carboxamide 2-ETHOXY-5-ETHYL-N-((1-ETHYLPYRROLIDIN-2-YL)METHYL)-6-HYDROXY-3-IODOBENZAMIDE HYDROCHLORIDE
CAS	122898-67-3
EINECS	694-655-5
Chemical Formula	C20H26N2O4
Molecular Weight	358.43
inchi	InChI=1/C20H26N2O4/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4/h5-10,13H,11-12,14H2,1-4H3,(H,21,23)
Package	Inquiry
Price	Get quote
Descriptions	Itopride Itopride MedChemExpress (MCE) HY-B0732A 122898-67-3 HSR803 free base Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Itopride Itopride MedChemExpress (MCE) HY-B0732A 122898-67-3 HSR803 free base Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD). Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3]. Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3]. Itopride (30 mg/kg p.o.) significantly accelerates gastric emptying compared with the vehicle group[4]. Itopride (30 mg/kg p.o.) displays Cmax of 358 ‰, T1/2 of 24.9 min[4]. AChE D2 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Iwanaga Y, et al. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990 Aug 99(2):401-8. [Content Brief] [2]. Kim YS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21 11(27):4210-4. [Content Brief] [3]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30 49(3):472-8. [Content Brief] [4]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct 31(10):1917-22. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact