Protriptyline MedChemExpress (MCE)

Product Name	PROTRIPTYLINE
Synonyms	PROTRIPTYLINE
CAS	438-60-8
EINECS
Chemical Formula	C19H21N
Molecular Weight	263.38
inchi
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Descriptions	Protriptyline Protriptyline MedChemExpress (MCE) HY-B0949A 438-60-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Protriptyline Protriptyline MedChemExpress (MCE) HY-B0949A 438-60-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease. Protriptyline (0-70 μM 24 hours PC3 cells) causes cytotoxicity in PC3 cells[2]. Protriptyline (10 mg/kg i.p. for 21 days rat model of AD) improves spatial learning and retention memory in STZ treated rats[3]. AChE 0.06 mM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20 9(8):e105196. [2]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015 35(5):429-34. [Content Brief] [3]. Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1 1754:147261. [Content Brief]
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Last Update	2025-05-21 16:50:25

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