122306-01-8
(6-Bromo-pyridin-3-YL)-Methanol
CAS: 122306-01-8
Molecular Formula: C6H6BrNO
122306-01-8 - Names and Identifiers
| Name | (6-Bromo-pyridin-3-YL)-Methanol |
| Synonyms | 6-Bromo-3-pyridinemethanol 2-Bromopyridine-5-methanol 6-BroMopyridine-3-Methanol (6-BroMo-3-pyridyl)Methanol (6-BROMO-PYRIDIN-3-YL)-METHANOL (6-Bromo-pyridin-3-YL)-Methanol (2-Bromo-pyridin-5-YL)-Methanol (2-BROMO-PYRIDIN-5-YL)-METHANOL 2-Bromo-5-(hydroxymethyl)pyridine |
| CAS | 122306-01-8 |
| InChI | InChI=1/C6H6BrNO/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2 |
| InChIKey | QPPDKOIDAYZUHN-UHFFFAOYSA-N |
122306-01-8 - Physico-chemical Properties
| Molecular Formula | C6H6BrNO |
| Molar Mass | 188.02 |
| Density | 1.668±0.06 g/cm3(Predicted) |
| Melting Point | 48-51℃ |
| Boling Point | 314.3±27.0 °C(Predicted) |
| Flash Point | >110℃ |
| Vapor Presure | 0.0002mmHg at 25°C |
| Appearance | Solid |
| Color | White to Light yellow to Light orange |
| pKa | 13.29±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.598 |
| MDL | MFCD04974508 |
122306-01-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
122306-01-8 - Introduction
6-Bromo-3-hydroxymethylpyridine is an organic compound with the chemical formula C6H6BrNO, also known as phenanthrene.
Its properties are as follows:
1. appearance: colorless to light yellow liquid.
2. Boiling point: 212-215°C.
3. density: 1.699g/cm³.
4. Solubility: Soluble in water and common organic solvents, such as ethanol and dimethylformamide.
6-bromo-3-hydroxymethylpyridine is mainly used as an intermediate in organic synthesis. It is useful for the preparation of other organic compounds, such as pyridines, metal complexes and pharmaceuticals. Due to its special properties in organic reactions, it can be used to synthesize complex organic molecules.
There are many methods for preparing this compound. One of the commonly used methods is to react pyridine and acetonitrile with hydrogen bromide to produce 6-bromo-3-pyridinecarbonitrile, which is then reduced to 6-bromo-3-hydroxymethylpyridine. Other methods include pyridine cyclization of carbamates and palladium-catalyzed coupling reactions, among others.
Regarding safety information, 6-bromo-3-hydroxymethylpyridine is an organic bromide and has certain toxicity. Therefore, the following points should be paid attention to during use and storage:
1. Avoid inhalation, skin contact and ingestion, and wear appropriate personal protective equipment.
2. Maintain good ventilation conditions during operation to prevent the accumulation of gas or vapor.
3. Store in a sealed container, away from fire and oxidant.
4. Do not store or contact with strong oxidizing agents and strong reducing agents to avoid dangerous reactions.
Its properties are as follows:
1. appearance: colorless to light yellow liquid.
2. Boiling point: 212-215°C.
3. density: 1.699g/cm³.
4. Solubility: Soluble in water and common organic solvents, such as ethanol and dimethylformamide.
6-bromo-3-hydroxymethylpyridine is mainly used as an intermediate in organic synthesis. It is useful for the preparation of other organic compounds, such as pyridines, metal complexes and pharmaceuticals. Due to its special properties in organic reactions, it can be used to synthesize complex organic molecules.
There are many methods for preparing this compound. One of the commonly used methods is to react pyridine and acetonitrile with hydrogen bromide to produce 6-bromo-3-pyridinecarbonitrile, which is then reduced to 6-bromo-3-hydroxymethylpyridine. Other methods include pyridine cyclization of carbamates and palladium-catalyzed coupling reactions, among others.
Regarding safety information, 6-bromo-3-hydroxymethylpyridine is an organic bromide and has certain toxicity. Therefore, the following points should be paid attention to during use and storage:
1. Avoid inhalation, skin contact and ingestion, and wear appropriate personal protective equipment.
2. Maintain good ventilation conditions during operation to prevent the accumulation of gas or vapor.
3. Store in a sealed container, away from fire and oxidant.
4. Do not store or contact with strong oxidizing agents and strong reducing agents to avoid dangerous reactions.
Last Update：2024-04-09 21:04:16
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