145525-41-3
Mitiglinide Calcium
CAS: 145525-41-3
Molecular Formula: (C19H24NO3)2.Ca
145525-41-3 - Names and Identifiers
| Name | Mitiglinide Calcium |
| Synonyms | Mitiglinide calcium Mitiglinide Calcium MITIGLINIDE CALCIUM HYDRATE (2S)-Mitiglinide-d5 Calcium Salt calcium 2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate calcium bis{(2S)-2-benzyl-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxobutanoate} calcium 4-(1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl)-4-oxo-2-(phenylmethyl)butanoate Monocalcium bis[(2S)-2-benzyl-3-(cis-hexahydro isoindolin -2-carbonyl)propionate]dihydrate (alphaS,3aR,7aS)-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic Acid Calcium Salt 2H-isoindole-2-butanoic acid, octahydro-gamma-oxo-alpha-(phenylmethyl)-, (alphaS,3aR,7aS)-, calcium salt (as,3ar,7as)-octahydro-gamma-oxo-alpha-(phenylmethyl)-2h-isoindole-2-butanoic acid calcium salt dihydrate |
| CAS | 145525-41-3 |
| EINECS | 692-046-9 |
| InChI | InChI=1/C19H25NO3.Ca/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14;/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23);/q;+2/t15-,16+,17-;/m0./s1 |
145525-41-3 - Physico-chemical Properties
| Molecular Formula | (C19H24NO3)2.Ca |
| Molar Mass | 668.88 |
| Density | 1.175 |
| Melting Point | 146-148°C |
| Boling Point | 519.6°C at 760 mmHg |
| Flash Point | 268°C |
| Solubility | DMSO: ≥10mg/mL at warmed to 60°C |
| Vapor Presure | 1.27E-11mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Inert atmosphere,Room Temperature |
| Use | For the total synthesis of new drugs against type II diabetes |
| In vitro study | Mitiglinide Calcium inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC 50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells. |
| In vivo study | Mitiglinide Calcium (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. Animal Model: Pregnant Wistar rats (12 weeks) Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration: Oral administration Result: Dose-dependently suppressed AUC glucose levels. |
145525-41-3 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
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Multiple SpecificationsSpot supply
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View History
145525-41-3
380894-77-9
113770-87-9
84057-81-8
2765502-85-8
17768-36-4
氨溴索
130980-01-7
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CHLOROACETYL-13C2 CHLORID
380894-77-9
113770-87-9
84057-81-8
2765502-85-8
17768-36-4
氨溴索
130980-01-7
Thioacetamide
CHLOROACETYL-13C2 CHLORID