193693-67-3

193693-67-3 - Names and Identifiers

Name	(R)-1-FMOC-PIPERIDINE-3-CARBOXYLIC ACID
Synonyms	FMOC-D-NIPC-OH FMOC-(R)-NIP-OH (r)-fmoc-nip-oh FMOC-(R)-NIPECOTIC ACID FMOC-(R)-PIPERIDINE 3-CARBOXYLIC ACID (R)-N-FMOC-PIPERIDINE-3-CARBOXYLIC ACID (R)-1-FMOC-PIPERIDINE-3-CARBOXYLIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-D-NIPECOTIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-(R)-NIPECOTIC ACID (R)-N-(9-FLUORENYLMETHYLOXYCARBONYL)-NIPECOTIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-D-3-PIPERIDINECARBOXYLIC ACID (R)-N-(9-FLUORENYLMETHYLOXYCARBONYL)-PIPERIDINE-3-CARBOXYLIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-N-(R)-PIPERIDINE-3-CARBOXYLIC ACID (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-(9H-FLUOREN-9-YLMETHYL) ESTER (R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-3-carboxylic acid
CAS	193693-67-3
InChI	InChI=1/C21H21NO4/c23-20(24)14-6-5-11-22(12-14)21(25)26-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19H,5-6,11-13H2,(H,23,24)/t14-/m1/s1

193693-67-3 - Physico-chemical Properties

Molecular Formula	C21H21NO4
Molar Mass	351.4
Density	1.293±0.06 g/cm3(Predicted)
Boling Point	561.6±43.0 °C(Predicted)
BRN	7945846
pKa	4.47±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.62
Physical and Chemical Properties	Storage Conditions: 2-8 ℃ WGK Germany:3

193693-67-3 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	29242990
Hazard Class	IRRITANT

193693-67-3 - Introduction

The chemical name is (R)-1-(9H-fluoren-1-yl)methoxycarbonyl)piperidine-3-carboxylic ACID, which is an organic compound.

Nature:
-Appearance: colorless crystal
-Molecular formula: C, H, N, O
-Molecular weight: 334.39g/mol
-Melting point: 128-130 ° C
-Stability: stable, avoid contact with oxidants

Use:
(R)-ACID is a chiral reagent widely used in the field of organic synthesis. It is often used as a reagent for the resolution of chiral ketones to produce compounds with high enantiomeric purity. In addition, it can be used to synthesize chiral antibiotics, chiral drugs and other bioactive compounds.

Method:
(R)-ACID preparation can be carried out by the following steps:
1. At low temperature, piperidine is reacted with N-chloroformyl piperidine to obtain N-chloroformyl compound.
2. Add fluorene methanol into the reaction system, and carry out bromination reaction with NBS(N-bromosuccinimide) on the mica plate to obtain the brominated compound of N-chloroformyl compound.
3. Finally, the bromide is reacted with copper formate to obtain the target product.

Safety Information:
(R)-Toxicological properties and safety of ACID are not yet available for reference. In handling and use, appropriate laboratory safety measures should be taken, such as wearing protective glasses, gloves and laboratory coats to prevent inhalation, ingestion or contact with skin.

Last Update：2024-04-09 21:00:56