HC-030031
HC-030031
CAS: 349085-38-7
Molecular Formula: C18H21N5O3
HC-030031 - Names and Identifiers
HC-030031 - Physico-chemical Properties
| Molecular Formula | C18H21N5O3 |
| Molar Mass | 355.39 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 221-223°C |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | White solid |
| Color | white to beige |
| pKa | 13.71±0.70(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| MDL | MFCD02007349 |
| Use | HC-030031 |
| In vitro study | HC-030031 rapidly and reversibly blocks the inward and outward currents induced by AITC or Formalin, and also inhibits the TRPA1 activation induced by N-methylmaleimide and electrophilic prostaglandins. HC-030031 did not inhibit TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channel-mediated currents. |
| In vivo study | HC-030031 may be provided to the animal by oral administration, inhalation or injection. HC-030031 chronic inflammatory or neuropathic pain rat model was treated orally at a dose of 100 mg/kg, which significantly reversed the mechanical pain sensitivity, while the local injection (100 μg) into the inflamed mouse hind paw, attenuates toxic-mechanical hyperalgesia, but not thermal hyperalgesia. |
HC-030031 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
HC-030031 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.814 ml | 14.069 ml | 28.138 ml |
| 5 mM | 0.563 ml | 2.814 ml | 5.628 ml |
| 10 mM | 0.281 ml | 1.407 ml | 2.814 ml |
| 5 mM | 0.056 ml | 0.281 ml | 0.563 ml |
Last Update：2024-01-02 23:10:35
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