L-异闪白氨基酸
L-异亮氨酸(L-Isoleucine)
CAS: 73-32-5;131598-62-4
化学式: C6H13NO2
性质
本品为白色结晶或结晶性粉末；无臭，味微苦。熔点284℃（分解），168～170℃升华。在水中微溶(4.12%，25℃)，在乙醇和乙醚中几乎不溶。它属于必需氨基酸，是三个支链氨基酸之一，氧化分解可释放较多能量，每摩尔异亮氨酸可产生43mol ATP。其代谢场所主要在肌肉，是生糖兼生酮氨基酸，代谢过程既释出乙酰CoA，又生成琥珀酸。它有促进胰岛素分泌的作用。缺乏L_异亮氨酸会引起骨骼肌障碍。它与另两种支链氨基酸相互之间有竞争性抑制作用。
制法
发酵法
用途
氨基酸类药。为营养增补剂，与其他碳水化合物、无机盐和维生素混合后供注射用。与其他氨基酸配伍共用于氨基酸输液和制剂。
安全性
- 补充氨基酸时，异亮氨酸与其他氯基酸保持适当比例，若异亮氨酸用量过大，反而产生营养对抗作用，引起其他氨基酸消耗及负氮平衡。
- 成人一次滴注15g时可引起发热反应和头痛、背痛。 遮光，密闭保存。
| 中文名 | L-异亮氨酸 |
| 英文名 | L-Isoleucine |
| 别名 | 异亮氨酸 L-异亮氨酸 L-异白氨酸 L-异闪白氨基酸 L-2-氨基-3-甲基戊酸 L-α-氨基-β-甲基戊酸 L-异亮氨酸(白色结晶粉末) L-异白氨酸,L-异闪白氨基酸,L-Α-氨基-Β-甲基戊酸 |
| 英文别名 | Ile L-Ile L-Ile-OH H-Ile-OH Isoleucine Isoleucina Isoleucinum iso-leucine L-Isoieucine L-ISOLEUSINE L-Isoleucine Isoleucine, L- L-(+)-Isoleucine Isoleucine (USP) (2S,3S)-(+)-Isoleucine 2-Amino-3-methylvaleric acid L-(+)-Isoleucine, Animal-Free L-2-Amino-3-methylvaleric Acid (2S,3S)-2-Amino-3-methylpentansαure 6-Amino-5-ethylamino-1-methyluracil (2S)-2-Amino-3-methylpentanoic acid (2S,3S)-a-Amino-b-methylvaleric acid (2S,3S)-2-amino-3-methyl-Pentanoic acid (2S,3S)-a-Amino-b-methyl-n-valeric acid (2s,3s)-alpha-amino-beta-merthylvalericacid (2s,3s)-alpha-amino-beta-methyl-n-valericacid |
| CAS | 73-32-5 131598-62-4 |
| EINECS | 200-798-2 |
| 化学式 | C6H13NO2 |
| 分子量 | 131.17 |
| InChI | InChI=1/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 |
| InChIKey | AGPKZVBTJJNPAG-WHFBIAKZSA-N |
| 密度 | 1.2930 (estimate) |
| 熔点 | 288 °C (dec.) (lit.) |
| 沸点 | 225.8±23.0 °C(Predicted) |
| 比旋光度 | 41 º (c=4, 6N HCl) |
| 闪点 | 168-170°C |
| 水溶性 | 41.2 g/L (50 ºC) |
| JECFA Number | 2118 |
| 溶解度 | 1 M HCl: 50 mg/mL |
| 折射率 | 40.5 ° (C=4, 6mol/L |
| 酸度系数 | 2.32, 9.76(at 25℃) |
| PH值 | 5.5-6.5 (40g/l, H2O, 20℃) |
| 存储条件 | Store below +30°C. |
| 外观 | 粉末 |
| 颜色 | White to Off-white |
| 最大波长(λmax) | λ: 260 nm Amax: 0.07λ: 280 nm Amax: 0.05 |
| Merck | 14,5179 |
| BRN | 1721792 |
| 物化性质 | 为白色结晶或结晶性粉末， 无臭， 味微苦。 mp284℃（分解）， 168-170℃升华。 在水中的溶解度为4.12%， 极难溶于乙醇和乙醚， [α]25D+39.5 (C=0.5-2.0g/ml, 5mol/L HCl), [α]25D+12.4 (C=0.5-2.0g/ml, H2O)， 等电点pI为6.02。 |
| MDL号 | MFCD00064222 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 40 - 少数报道有致癌后果。 |
| 安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S22 - 切勿吸入粉尘。 |
| WGK Germany | 3 |
| RTECS | NR4705000 |
| TSCA | Yes |
| 海关编号 | 29224995 |
| 上游原料 | 无水葡萄糖 液氨 |
| 下游产品 | L-亮氨酸 D-异亮氨酸 2-甲基正丁胺 L-异亮氨酸苄酯对甲苯磺酸盐 |
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L-异闪白氨基酸 - 性质
可信数据
本品为白色结晶或结晶性粉末；无臭，味微苦。熔点284℃（分解），168～170℃升华。在水中微溶(4.12%，25℃)，在乙醇和乙醚中几乎不溶。它属于必需氨基酸，是三个支链氨基酸之一，氧化分解可释放较多能量，每摩尔异亮氨酸可产生43mol ATP。其代谢场所主要在肌肉，是生糖兼生酮氨基酸，代谢过程既释出乙酰CoA，又生成琥珀酸。它有促进胰岛素分泌的作用。缺乏L_异亮氨酸会引起骨骼肌障碍。它与另两种支链氨基酸相互之间有竞争性抑制作用。
最后更新：2024-01-02 23:10:35
L-异闪白氨基酸 - 制法
可信数据
发酵法
最后更新：2022-01-01 11:10:04
L-异闪白氨基酸 - 用途
可信数据
氨基酸类药。为营养增补剂，与其他碳水化合物、无机盐和维生素混合后供注射用。与其他氨基酸配伍共用于氨基酸输液和制剂。
最后更新：2022-01-01 11:10:04
L-异闪白氨基酸 - 安全性
可信数据
- 补充氨基酸时，异亮氨酸与其他氯基酸保持适当比例，若异亮氨酸用量过大，反而产生营养对抗作用，引起其他氨基酸消耗及负氮平衡。
- 成人一次滴注15g时可引起发热反应和头痛、背痛。 遮光，密闭保存。
最后更新：2022-01-01 11:10:05
L-异闪白氨基酸 - 简介
L-异亮氨酸是一种非必需氨基酸，人体无法自行合成，需从食物中获取。它是由异亮氨酸合成酶催化顺式异构化而成的。
L-异亮氨酸在生物体内具有重要的生理功能。它是蛋白质的组成成分之一，参与蛋白质的合成和修复。L-异亮氨酸还参与体内代谢过程，能够促进肌肉生长和维持肌肉组织的正常功能。
L-异亮氨酸可以通过化学合成或微生物发酵的方式进行制备。化学合成方法主要是通过对手性化合物进行光学反应或酶催化反应来获得。
需要特别注意的是可能出现过敏反应的情况，在使用前应进行过敏测试。
L-异亮氨酸在生物体内具有重要的生理功能。它是蛋白质的组成成分之一，参与蛋白质的合成和修复。L-异亮氨酸还参与体内代谢过程，能够促进肌肉生长和维持肌肉组织的正常功能。
L-异亮氨酸可以通过化学合成或微生物发酵的方式进行制备。化学合成方法主要是通过对手性化合物进行光学反应或酶催化反应来获得。
需要特别注意的是可能出现过敏反应的情况，在使用前应进行过敏测试。
最后更新：2024-04-09 20:49:11
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产品名: 苏氨酸杂质4 (苏氨酸EP杂质D) 询盘产地: 湖北
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: 21204T
提供多种规格
产品名: 苏氨酸杂质4 (苏氨酸EP杂质D) 询盘产地: 湖北
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: 21204T
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