N-甲基-3-苯基-3-(4-三氟甲基苯氧基)-1-丙胺
氟西汀(Fluoxetine)
CAS: 54910-89-3
化学式: C17H18F3NO
| 中文名 | 氟西汀 |
| 英文名 | Fluoxetine |
| 别名 | 氟西汀 氟西丁 氟西汀盐酸盐 氟烷苯胺丙醚 氟西汀溶液,100PPM N-甲基-3-苯基-3-(对三氟甲基苯氧基)丙胺 (±)-N-甲基-Γ-[4-三氟甲基)苯氧基]苯丙胺 N-甲基-3-苯基-3-(4-三氟甲基苯氧基)-1-丙胺 |
| 英文别名 | FLUOXETINE Fluoxetine AURORA KA-7692 (+-)-benzenepropanamin METHYL-[3-PHENYL-3-(4-TRIFLUOROMETHYLPHENOXY)PROPYL]AMINE dl-3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine (+)or(-)-n-methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine (+)or(-)-n-methyl-3-phenyl-3-(alpha,alpha,alpha-trifluoro-p-tolyl)oxy)prop |
| CAS | 54910-89-3 |
| EINECS | 611-209-7 |
| 化学式 | C17H18F3NO |
| 分子量 | 309.33 |
| InChI | InChI=1/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 |
| 密度 | 1.159±0.06 g/cm3(Predicted) |
| 熔点 | 158 °C |
| 沸点 | 395.1±42.0 °C(Predicted) |
| 酸度系数 | 10.05±0.10(Predicted) |
| 存储条件 | 2-8°C(protect from light) |
| 物化性质 | 盐酸氟西汀(Fluoxetine Hydrochloride)：C17H18F3NO?HCl。[59333-67-4]。白色至类白色结晶性固体，熔点158.4～158.9℃。易溶于甲醇或乙醇，溶于乙腈、丙酮或氯仿，微溶于乙酸乙酯、二氯甲烷或水(with sonieation at pHl.2，4.5，7.0)，几不溶于环己烷、己烷或甲苯。溶解度(mg/m1)：甲醇和乙醇＞100，丙酮、乙腈和氯仿33～100，二氯甲烷5～10，水1～2，乙酸乙酯2～2.5，环己烷、己烷和甲苯0.5～0.67。水中最大溶解度：14mg/ml。UV最大吸收(甲醇)：227，264，268，275nm(E1cm1%372.0，29.2，29.3，21.5)。急性毒性LD50小鼠，大鼠(mg/kg)：248，452口服。草酸氟西汀(Fluxetine Oxalate)：C17H18F3NO?C2H2O4。从乙酸乙酯-甲醇结晶，熔点179～182℃(分解)。 |
| 上游原料 | 氯化亚砜 一甲胺 碘化钾 苯丙酮 溴化氰 乙硼烷 4-氟苯酚 盐酸氟西汀 硫酸 氢氧化钠 盐酸 对三氟甲基苯酚 |
| 参考资料 展开查看 | 1. Jina Yang, Danyang Liu, Wenbin Jin, Qisheng Zhong, Ting Zhou, A green and efficient pseudotargeted lipidomics method for the study of depression based on ultra-high performance supercritical fluid chromatography-tandem mass spectrometry, Journal of Pharmac 2. [IF=4.268] Yan-Ling Qiao et al."Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT1A receptor: Insights from transcriptomics."Phytomedicine. 2021 Jan;81:153436 3. [IF=4.142] Liu Danyang et al."A high coverage pseudotargeted lipidomics method based on three-phase liquid extraction and segment data-dependent acquisition using UHPLC-MS/MS with application to a study of depression rats."Anal Bioanal Chem. 2021 Jun;413(15):3975-3 4. [IF=3.935] Jina Yang et al."A green and efficient pseudotargeted lipidomics method for the study of depression based on ultra-high performance supercritical fluid chromatography-tandem mass spectrometry."J Pharmaceut Biomed. 2021 Jan;192:113646 5. [IF=3.935] Wenbin Jin et al."Determination of inflammation-related lipids in depressive rats by on-line supercritical fluid extraction-supercritical fluid chromatography-tandem mass spectrometry."J Pharmaceut Biomed. 2021 Sep;203:114210 6. [IF=3.826] Zhen‐Long Yu et al."Uncarialins J‐M from Uncaria rhynchophylla and their anti‐depression mechanism in unpredictable chronic mild stress‐induced mice via activating 5‐HT1A receptor."Chinese J Chem. 2021 May;39(5):1331-1343 7. [IF=3.645] Jina Yang et al."Enhanced pseudotargeted analysis using a segment data dependent acquisition strategy by liquid chromatography–tandem mass spectrometry for a metabolomics study of liquiritin in the treatment of depression."J Sep Sci. 2020 Jun;43(11):2088- 8. [IF=2.506] Jiang Yu et al."Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect."J Chem-Ny. 2022;2022:7651553 |
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N-甲基-3-苯基-3-(4-三氟甲基苯氧基)-1-丙胺的上游原料
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