腺甙
腺苷(Adenosine)
CAS: 58-61-7
化学式: C10H13N5O4
性质
- 本品为白色结晶性粉末，无臭，味苦。熔点234～235℃。易溶于水，几乎不溶于乙醚、氯仿和乙醇。
- 本品可直接进入心肌磷酸化为腺苷酸，参与心肌能量代谢，扩张冠状血管，增加冠脉血流量。由于在体内易被腺苷脱氨酶破坏，故作用不能持久。它也具有周围血管扩张作用，较冠脉扩张作用为弱，也产生短暂降压作用。此外，它还稍有减弱心肌收缩力的作用。
用途
- 治疗心绞痛、心肌梗塞、冠脉功能不全、动脉硬化、原发性高血压、脑血管障碍、中风后遗症、进行性肌肉萎缩等。
- 用途、用法及剂量 口服，每日60～90mg，分3次服用，轻症每日30mg，重症每日12 0mg。
安全性
房室传导阻滞及急性心肌梗塞患者禁用。
| 中文名 | 腺苷 |
| 英文名 | Adenosine |
| 别名 | 腺苷 胰苷 腺甙 腺素苷 腺呤配糖 腺嘌呤核苷 腺尿环核苷 D-腺嘌呤核苷 腺苷, 腺苷脱氢酶底物 ADENOSINE 腺苷 腺嘌呤核苷(腺苷)(标准品) 9-β-D-呋喃核糖基腺嘌呤 腺嘌呤-9-1'-Β-核呋喃糖苷 9-beta-D-呋喃核糖基腺嘌呤 6-氨基-9-Β-D-呋喃核糖基-9H-嘌呤 |
| 英文别名 | AR Adenosine D-ADENOSINE ADENINENUCLEOSIDE adenosine free base 9-BETA-D-RIBOFURANOSYLADENINE ADENOSINE extrapure for biochemistry 9-alpha-D-lyxofuranosyl-9H-purin-6-amine 6-Amino-9-(beta-D-ribofuranosyl)9H-purine Adenine riboside, Adenine-9-beta-ribofuranoside 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside (2R,3R,4S,5R)-2-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL |
| CAS | 58-61-7 |
| EINECS | 200-389-9 |
| 化学式 | C10H13N5O4 |
| 分子量 | 267.24 |
| InChI | InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6+,7+,10+/m1/s1 |
| InChIKey | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| 密度 | 1.3382 (rough estimate) |
| 熔点 | 234-236 °C (lit.) |
| 沸点 | 410.43°C (rough estimate) |
| 比旋光度 | D11 -61.7° (c = 0.706 in water); 9D -58.2° (c = 0.658 in water) |
| 闪点 | 362.8°C |
| 水溶性 | Soluble in water, ammonium hydroxide and dimethyl sulfoxide. Insoluble in ethanol. |
| 蒸汽压 | 3.26E-19mmHg at 25°C |
| 溶解度 | 微溶于水，溶于热水，几乎不溶于乙醇 (96%) 和二氯甲烷。它溶解在稀无机酸中。 |
| 折射率 | 1.7610 (estimate) |
| 酸度系数 | 3.6, 12.4(at 25℃) |
| 存储条件 | 2-8°C |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 外观 | 结晶性粉末 |
| 颜色 | White |
| Merck | 14,153 |
| BRN | 93029 |
| 物化性质 | 从水结晶，熔点234--235℃。[α]D11-61.7°(C=0.706，水)；[α] D9-58.2°(C=0.658，水)。几不溶于醇。 |
| MDL号 | MFCD00005752 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| WGK Germany | 2 |
| RTECS | AU7175000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| 海关编号 | 29389090 |
| 下游产品 | 人抗糖蛋白抗体(GP)ELISA试剂盒 2-(6-ethylaminopurin-9-yl)-5-(hydroxymethyl)oxol 尿苷酸(2'-和3'-位的混合物) |
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Wen Jie Zhang, Shi Gang Liu, Lei Han, Hong Qun Luo, Nian Bing Li,A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion,Sensors and Ac 36. Qi, Lubin, et al. "Detection of biomarkers in blood using liquid crystals assisted with aptamer-target recognition triggered in situ rolling circle amplification on magnetic beads." Analytical chemistry 91.18 (2019): 11653-11660. 37. Qin Hu, Lu Gao, Sheng-qi Rao, Zhen-quan Yang, Tao Li, Xiaojuan Gong, Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect, Food Chemistry, Volume 280, 2019, Pages 195-202, ISSN 0308-8146, htt 38. Liu, Mengyujie, et al. "Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach." Phytochemical Analysis 31.6 (2020): 835-845.https://doi.org/10.1002/pca.2949 39. Hengqiang Zhao, Minmin Zhang, Qian Liu, Xiaoli Wang, Ruixuan Zhao, Yanling Geng, Tityee Wong, Shengbo Li & Xiao Wang (2018) A comprehensive screening shows that ergothioneine is the most abundant antioxidant in the wild macrofungus Phylloporia ribis Ryvard 40. Xia, Yuanyuan, et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." Journal of Food Composition and Analysis 62 (2017): 134-142.https://doi.org/10.1016 41. Wang, Chengcheng, et al. "Distribution patterns for metabolites in medicinal parts of wild and cultivated licorice." Journal of pharmaceutical and biomedical analysis 161 (2018): 464-473.https://doi.org/10.1016/j.jpba.2018.09.004 42. 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腺甙 - 性质
可信数据
- 本品为白色结晶性粉末，无臭，味苦。熔点234～235℃。易溶于水，几乎不溶于乙醚、氯仿和乙醇。
- 本品可直接进入心肌磷酸化为腺苷酸，参与心肌能量代谢，扩张冠状血管，增加冠脉血流量。由于在体内易被腺苷脱氨酶破坏，故作用不能持久。它也具有周围血管扩张作用，较冠脉扩张作用为弱，也产生短暂降压作用。此外，它还稍有减弱心肌收缩力的作用。
最后更新：2024-01-02 23:10:35
腺甙 - 用途
可信数据
- 治疗心绞痛、心肌梗塞、冠脉功能不全、动脉硬化、原发性高血压、脑血管障碍、中风后遗症、进行性肌肉萎缩等。
- 用途、用法及剂量 口服，每日60～90mg，分3次服用，轻症每日30mg，重症每日12 0mg。
最后更新：2022-01-01 11:12:34
腺甙 - 安全性
可信数据
房室传导阻滞及急性心肌梗塞患者禁用。
最后更新：2022-01-01 11:12:34
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产品名: 腺苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IA01001
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提供多种规格现货供应
产品名: 腺苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IA01001
产地: 北京
包装: 1ml/瓶
规格: IA01001-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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