房室传导阻滞及急性心肌梗塞患者禁用。
中文名 | 腺苷 |
英文名 | Adenosine |
别名 | 腺苷 胰苷 腺甙 腺素苷 腺呤配糖 腺嘌呤核苷 腺尿环核苷 D-腺嘌呤核苷 腺苷, 腺苷脱氢酶底物 ADENOSINE 腺苷 腺嘌呤核苷(腺苷)(标准品) 9-β-D-呋喃核糖基腺嘌呤 腺嘌呤-9-1'-Β-核呋喃糖苷 9-beta-D-呋喃核糖基腺嘌呤 6-氨基-9-Β-D-呋喃核糖基-9H-嘌呤 |
英文别名 | AR Adenosine D-ADENOSINE ADENINENUCLEOSIDE adenosine free base 9-BETA-D-RIBOFURANOSYLADENINE ADENOSINE extrapure for biochemistry 9-alpha-D-lyxofuranosyl-9H-purin-6-amine 6-Amino-9-(beta-D-ribofuranosyl)9H-purine Adenine riboside, Adenine-9-beta-ribofuranoside 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside (2R,3R,4S,5R)-2-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL |
CAS | 58-61-7 |
EINECS | 200-389-9 |
化学式 | C10H13N5O4 |
分子量 | 267.24 |
InChI | InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6+,7+,10+/m1/s1 |
InChIKey | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
密度 | 1.3382 (rough estimate) |
熔点 | 234-236 °C (lit.) |
沸点 | 410.43°C (rough estimate) |
比旋光度 | D11 -61.7° (c = 0.706 in water); 9D -58.2° (c = 0.658 in water) |
闪点 | 362.8°C |
水溶性 | Soluble in water, ammonium hydroxide and dimethyl sulfoxide. Insoluble in ethanol. |
蒸汽压 | 3.26E-19mmHg at 25°C |
溶解度 | 微溶于水,溶于热水,几乎不溶于乙醇 (96%) 和二氯甲烷。它溶解在稀无机酸中。 |
折射率 | 1.7610 (estimate) |
酸度系数 | 3.6, 12.4(at 25℃) |
存储条件 | 2-8°C |
稳定性 | 稳定。与强氧化剂不相容。 |
外观 | 结晶性粉末 |
颜色 | White |
Merck | 14,153 |
BRN | 93029 |
物化性质 | 从水结晶,熔点234--235℃。[α]D11-61.7°(C=0.706,水);[α] D9-58.2°(C=0.658,水)。几不溶于醇。 |
MDL号 | MFCD00005752 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 2 |
RTECS | AU7175000 |
FLUKA BRAND F CODES | 10-23 |
TSCA | Yes |
海关编号 | 29389090 |
下游产品 | 阿糖腺苷 N6-苯甲酰基腺苷 2-(6-ethylaminopurin-9-yl)-5-(hydroxymethyl)oxol 尿苷酸(2'-和3'-位的混合物) |
参考资料 展开查看 | 1. 何昱 周惠芬 黄丽娜 等. HPLC-DAD法同时测定谷红注射液中7个组分的含量[J]. 药物分析杂志 2015 035(006):954-959. 2. 王锐轩 薛海萍 丁越 等. HPLC法测定复合阿胶泡腾片中核苷类化合物的含量[J]. 中国中医药科技 2019 026(005):686-688. 3. 张艳丽 杨雁芸 白志尧 等. UPLC-MS/MS同时测定熟地黄中8个核苷类成分的含量[J]. 药物分析杂志 2019 039(004):608-614. 4. 郭涛 张龙 王兵 等. 不同培养基培育蛹虫草中的虫草素和腺苷含量测定[J]. 蚕业科学 2011 37(006):1117-1122. 5. 刘红 马辉 曹宏 等. 不同蛹虫草杂粮培养基的生产性能及滋味物质分析[J]. 食品工业科技 2019(12). 6. 陈家念 张璇 蔡豪斌 等. 冬虫夏草菌丝体水提醇沉物体外抗肿瘤活性研究[J]. 药物评价研究 2014 37(2):108-112. 7. 冯卫生, 李方, 郭孟焕,等. 怀山药中的一个新吡嗪衍生物[J]. 药学学报, 2017(08):101-103. 8. 樊铭聪. 杏鲍菇副产物免疫活性物质追踪与结构鉴定[D]. 青岛农业大学, 2016. 9. 乐昕, 袁蜜, 支月娥,等. 栽培基质及碳源对蛹虫草子实体中主要有效成分的影响[J]. 食品科技, 2014, 039(002):2-7. 10. 所千贺, 肖会敏, 王四旺. 脉络通胶囊HPLC指纹图谱和6种成分的定量研究[J]. 西北药学杂志, 2020(2):164-168. 11. 申鸿, 张龙, 王兵,等. 蚕体和蛹粉代料培养基上的蛹虫草生长状况与品质检测[J]. 蚕业科学, 2012, 38(001):130-134. 12. 潘琦, 孙兰凤. 蛹虫草中4种核苷的含量分析[J]. 中国当代医药, 2015, 000(009):85-87. 13. 惠觅宙, 秦璐楠, 高辰哲,等. 重组人碱性磷酸酶表达及其调节人白细胞释放TNF-α活性研究[J]. 东北农业大学学报, 2020, v.51;No.301(03):56-63. 14. 张磊, 王燕华, 刘畅,等. 驴皮胶及鹿皮胶的化学品质分析与评价[J]. 食品科学, 2018, 039(022):57-63. 15. 袁蜜, 乐昕, 徐鲁荣,等. 高效液相色谱法同时测定蛹虫草子实体中腺苷和虫草素含量[J]. 食品科学, 2013(14):306-310. 16. 张艳丽 杨雁芸 白志尧 等. UPLC-MS/MS法同时测定党参中7种核苷的含量[J]. 中国医药科学 2018 v.8;No.181(13):68-71. 17. 郑晓珂 杨雁芸 张艳丽 等. UPLC-MS/MS法同时测定生地黄饮片中7种核苷类成分的含量[J]. 中药材 2018 041(005):1142-1144. 18. 高坤 宫瑞泽 李珊珊 等. UPLC法同时测定人参中13种核苷类成分[J]. 食品工业 2019. 19. 孔静,贺晶,谭立,申立峰,李倩,张元元,吕珊,武秋红,陈梦杰,刘璐,李文霞,路东波,石任兵,姜艳艳.基于金花葵核苷类成分的质量表征关联分析研究[J].北京中医药大学学报,2017,40(05):420-427 20. 黄涵, 王宇卿. 瓜蒌薤白半夏胶囊提取工艺的优化[J]. 中成药, 2019, 41(02):182-185. 21. 李明波, 段晓蓓, 张海林,等. 超声提取蝉花中核苷碱基的工艺条件[J]. 贵州农业科学, 2014, 000(003):154-157. 22. 代莉莉, 金珊霞, 范梦莹,等. 季铵化β-环糊精接枝壳聚糖涂层用于毛细管电泳分离的研究[J]. 分析试验室, 2017, 08(v.36):15-18. 23. 甄子萱 葛淑俊. 不同产地掌叶半夏中4种核苷类成分和葫芦巴碱测定[J]. 中药材 2017 v.40;No.406(12):85-88. 24. 虞小静, 张冬月, 李思雨,等. 天麻水提物HPLC指纹图谱的建立及其真伪鉴别[J]. 中成药, 2018, 40(12):2698-2702. 25. 张雪婷, 钟承赞, 杨明,等. 金水宝胶囊生产过程中质量控制方法的建立[J]. 中国实验方剂学杂志, 2020(4). 26. 马蕊 杨珂 李文辉 等. 不同生长期怀山药化学成分分析[J]. 食品研究与开发 2019. 27. 马蕊, 王露露, 陈随清. 山药商品规格及其质量特性分析[J]. 中成药 2020年42卷7期, 1936-1942页, ISTIC PKU CSCD CA, 2020. 28. 谭立,孔静,冯朵,刘璐,吕珊,张元元,石任兵.基于抗心肌缺血作用的金花葵制备物药物质量表征分析[J].世界科学技术-中医药现代化,2017,19(03):522-528. 29. 孙雯, 李莎, 杨飞燕,等. 自制多脏器保存液对低温大鼠睾丸氧自由基表达的影响[J]. 中华男科学杂志, 2011, 17(007):655-657. 30. 孙雯, 张金萍, 揭芳,等. 自制多脏器保存液对大鼠睾丸一氧化氮合酶的影响[J]. 中国组织工程研究, 2011, 15(031):5813-5816. 31. 王露佳, 孙雯, 张金萍,等. 自制移植肝低温保存液对氧自由基的影响[J]. 中国组织工程研究, 2013, 000(005):837-842. 32. 刘生,徐伟琴,邓少欢,惠爱玲,张文成.不同产地蛹虫草鲜干品核苷类含量测定[J].食品工业,2021,42(01):226-229. 33. 马明,张开雪,熊超,邬兰,孙伟,马伟.板蓝根标准汤剂质量标准研究[J].中华中医药杂志,2020,35(10):5139-5144. 34. 刘松鑫,宫瑞泽,王泽帅,张磊,刘畅,陆雨顺,孙印石.基于主成分分析和判别分析对花鹿茸和马鹿茸9类化学成分对比研究[J].中草药,2021,52(01):82-90. 35. Wen Jie Zhang, Shi Gang Liu, Lei Han, Hong Qun Luo, Nian Bing Li,A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion,Sensors and Ac 36. Qi, Lubin, et al. "Detection of biomarkers in blood using liquid crystals assisted with aptamer-target recognition triggered in situ rolling circle amplification on magnetic beads." Analytical chemistry 91.18 (2019): 11653-11660. 37. Qin Hu, Lu Gao, Sheng-qi Rao, Zhen-quan Yang, Tao Li, Xiaojuan Gong, Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect, Food Chemistry, Volume 280, 2019, Pages 195-202, ISSN 0308-8146, htt 38. Liu, Mengyujie, et al. "Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach." Phytochemical Analysis 31.6 (2020): 835-845.https://doi.org/10.1002/pca.2949 39. Hengqiang Zhao, Minmin Zhang, Qian Liu, Xiaoli Wang, Ruixuan Zhao, Yanling Geng, Tityee Wong, Shengbo Li & Xiao Wang (2018) A comprehensive screening shows that ergothioneine is the most abundant antioxidant in the wild macrofungus Phylloporia ribis Ryvard 40. Xia, Yuanyuan, et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." Journal of Food Composition and Analysis 62 (2017): 134-142.https://doi.org/10.1016 41. Wang, Chengcheng, et al. "Distribution patterns for metabolites in medicinal parts of wild and cultivated licorice." Journal of pharmaceutical and biomedical analysis 161 (2018): 464-473.https://doi.org/10.1016/j.jpba.2018.09.004 42. Hengqiang Zhao, Minmin Zhang, Qian Liu, Xiaoli Wang, Ruixuan Zhao, Yanling Geng, Tityee Wong, Shengbo Li & Xiao Wang (2018) A comprehensive screening shows that ergothioneine is the most abundant antioxidant in the wild macrofungus Phylloporia ribis Ryvard 43. [IF=7.514] Qin Hu et al."Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect."Food Chem. 2019 May;280:195 44. [IF=7.46] Wen Jie Zhang et al."A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion."Sensor Actuat B-Chem. 2019 Mar;283:215 45. [IF=4.556] Yuanyuan Xia et al."Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics."J Food Compos Anal. 2017 Sep;62:134 46. [IF=4.411] Yanling Zeng et al."Rapid Characterization of Components in Bolbostemma paniculatum by UPLC/LTQ-Orbitrap MSn Analysis and Multivariate Statistical Analysis for Herb Discrimination."Molecules. 2018 May;23(5):1155 47. [IF=4.411] Yujiao Hua et al."Quality Evaluation of Pseudostellariae Radix Based on Simultaneous Determination of Multiple Bioactive Components Combined with Grey Relational Analysis."Molecules. 2017 Jan;22(1):13 48. [IF=2.896] Ya-yun Chen et al."Determination of free amino acids and nucleosides and nucleobases in Annona squamosa L. fruitages from different regions in China by LC-QTRAP-MS/MS."Anal Methods-Uk. 2017 Jun;9(25):3862-3869 49. [IF=6.057] Yi Luo et al."PEGylation of boronate-affinity-oriented surface imprinting magnetic nanoparticles with improved performance."Talanta. 2022 Feb;238:122992 50. [IF=5.455] Zhang Xian et al."Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine."Chin Med-Uk. 2021 Dec;16(1):1-19 51. [IF=4.466] Yao Tan et al."Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice."J Proteome Res. 2021;20(1):645–660 52. [IF=4.411] Mengxia Tan et al."Quality Evaluation of Ophiopogonis Radix from Two Different Producing Areas."Molecules. 2019 Jan;24(18):3220 53. [IF=4.411] Shengxin Yin et al."Comparison of Multiple Bioactive Constituents in the Corolla and Other Parts of Abelmoschus manihot."Molecules. 2021 Jan;26(7):1864 54. [IF=4.142] Zhang Wen Jie et al."Ratiometric assay of mercury ion based on nitrogen-doped carbon dots with two different optical signals: second-order scattering and fluorescence."Anal Bioanal Chem. 2020 Jul;412(18):4375-4382 55. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 56. [IF=3.935] Biru Shi et al."Investigation on the stability in plant metabolomics with a special focus on freeze-thaw cycles: LC–MS and NMR analysis to Cassiae Semen (Cassia obtusifolia L.) seeds as a case study."J Pharmaceut Biomed. 2021 Sep;204:114243 57. [IF=3.24] Zhichen Cai et al."Metabolomics characterizes the metabolic changes of Lonicerae Japonicae Flos under different salt stresses."Plos One. 2020 Dec;15(12):e0243111 58. [IF=2.772] Mengyujie Liu et al."Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach."Phytochem Analysis. 2020 Nov;31(6):835-845 59. [IF=1.618] Wang Shengnan et al."Simultaneous Determination of Iridoid Glycosides, Phenylpropanoid Glycosides, Organic Acids, Nucleosides and Amino Acids in Scrophulariae Radix Processed by Different Processing Methods by HPLC-QTRAP-MS/MS."J Chromatogr Sci. 2021 Jun; 60. [IF=3.24] Yinfang Gao et al."Uricase-deficient rats with similarly stable serum uric acid to human’s are sensitive model animals for studying hyperuricemia."Plos One. 2022 Mar;17(3):e0264696 61. [IF=6.057] Zhi-Heng Pan et al."Poly(caffeic acid)-coated molecularly imprinted magnetic nanoparticles for specific and ultrasensitive detection of glycoprotein."Talanta. 2022 May;241:123240 62. [IF=6.529] Yarigui Bao et al."Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance."Biomed Pharmacother. 2022 Mar;147:112643 63. [IF=4.411] Nan Wu et al."Quality Evaluation of Taxilli Herba from Different Hosts Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis."Molecules. 2021 Jan;26(24):7490 64. [IF=3.373] Yiyuan Luo et al."Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis."PHYTOCHEMICAL ANALYSIS. 2022 Apr 05 65. [IF=6.475] Zhen Wu et al."How steaming and drying processes affect the active compounds and antioxidant types of Gastrodia elata Bl. f. glauca S. chow."FOOD RESEARCH INTERNATIONAL. 2022 Jul;157:111277 66. [IF=3.935] Min Zhang et al."Chemical profile and miscarriage prevention evaluation of Jiao-ai decoction, a classical traditional Chinese formula."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114832 |
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