Rhodamine B hydrazide is a water-soluble fluorescent probe used for the detection of copper, peroxynitrite, nitric oxide, hydrogen peroxide, glucose, diacetyl, and hemoglobin.
RGW 611 is an impurity of Nimorazole, which is an anti-infective agent against anaerobic bacteria and protozoa. Nimorazole is being researched for the treatment of head and neck cancer.
RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780.
RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 shows excellent pharmacokinetic and in vivo efficacy and has a favorable safety profile. RG7800 can correct alternative splicing of the human. Phase I/II clinical trials for the treatment of Spinal muscular atrophyis on-going.
RG108 is a DNA methyltransferase inhibitor with IC50 value of 115 nM. RG108 can enhance reprogramming of somatic cells to induced pluripotent stem (iPS) cells.
Retinyl acetate is a natural form of vitamin A, a group of unsaturated nutritional organic compounds that includes retinol, retinal, retinoic acid, as well as several provitamin A carotenoids and beta-carotene. Vitamin A has multiple functions: it is important for growth and development, for the maintenance of the immune system and good vision. Vitamin A is needed by the retina of the eye in the form of retinal, which combines with protein opsin to form rhodopsin, the light-absorbing molecule necessary for both low-light (scotopic vision) and color vision. It also functions as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells. It can absorb through the skin, resist keratinization, stimulate the growth of collagen and elastin, and increase the thickness of the epidermis and dermis. It enhances skin elasticity, effectively eliminates wrinkles, promotes skin renewal, and maintains skin vitality. It is used in eye cream, moisturizer, repair cream, shampoo, conditioner, etc.
Hydroxypinacolone Retinoate (HPR) is a revolutionary new retinoid. Compared with other vitamin A products, it can directly work through the excitatory receptor without metabolic transformation (generally retinoids need to be transformed in the skin in two steps). It is less irritating, highly potent, more stable, and less likely to be oxidized. It is a safe and effective anti-aging (effective in reducing fine lines and wrinkles, fading color spots) and anti-acne ingredient. Hydroxypinacolone retinoate, a derivative of retinol, regulates the metabolism of the epidermis and stratum corneum. It can be anti-aging, reduce sebum overflow, desalinate epidermal pigment, and play a role in preventing skin aging, preventing acne, whitening and lightening spots. It can be used to treat skin diseases.
Resazurin is a blue dye, itself weakly fluorescent until it is irreversibly reduced to the pink colored and highly red fluorescent resorufin. It can be used as an oxidation-reduction indicator in cell viability assays for both aerobic and anaerobic respiration.
TPX-0005 is an orally available and potent ATP-competitive inhibitor of ALK/ROS1/TRK (IC50= 5.3 nM for SRC, IC50= 1.01 nM, 1.26 nM and 1.08 nM for mutant ALKs including WT ALK, ALK G1202R and ALK L1196M, respectively).
An impurity of Repaglinide, an antidiabetic drug. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus.
Renzapride is a full 5-HT4 agonist and partial 5-HT3 antagonist. Renzapride has been used for the treatment of constipation-predominant irritable bowel syndrome (IBS-C).
Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells.
Remdesivir, an analog nucleotide inhibitor, with effectively antiviral activity in vitro against various virus, including Ebola virus, Marburg virus, HCoV-NL63, HCoV-OC43, HCoV-229E, Mouse hepatitis virus (MHV), SARS-CoV, MERS-CoV and related bat coronavirus, HKU5, and PDCoV (porcine delta-coronavirus). Remdesivir is also reported to have potential antiviral activity against a 2019 novel coronavirus (called 2019-nCoV, nCoV2019 or COVID-19).
Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally. By preventing LH-RH from binding with the LH-RH receptor in the anterior pituitary gland and suppressing the secretion of luteinizing hormone (LH) and follicle stimulation hormone (FSH) from the anterior pituitary gland, TAK-385 controls the effect of LH and FSH on the ovary, reduces the level of estrogen in blood, which is known to be associated with the development of endometriosis and uterine fibroids, and is expected to improve the symptoms of these disorders.
Relebactam, a diazabicyclooctane derivative, has a broad spectrum inhibitory activity against β-lactamases. It has been studied to be probably effective in the treatment of Gram-negative bacterial infections combinated with Primaxin.
Relamorelin is a synthetic, centrally penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR). It is potentially useful for the treatment of diabetic gastroparesis, chronic idiopathic constipation, and anorexia nervosa. It is a pentapeptide and an analogue of ghrelin. It produces increases in plasma growth hormone, prolactin, and cortisol levels, and increases appetite in humans. It is under development by Rhythm Pharmaceuticals and is in phase II clinical trials.
A metabolite of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.
Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2.
An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.
Rebaudioside M is a natural sweetener extracted from the stevia plant. It is commonly used as a substitute for sugar in various food and beverage products due to its high sweetness and low calorie content. Additionally, studies have shown that rebaudioside M may have potential applications in the treatment of diabetes and obesity due to its ability to regulate blood sugar levels and improve insulin sensitivity.
Rebaudioside I, a plant-derived non-caloric sweetener extracted from Stevia rebaudiana leaves, has been widely adopted in food and beverage industries as a sugar supplement. Beyond its sweetness, this compound demonstrates tremendous potential for managing type 2 diabetes, by enhancing insulin secretion and improving glucose tolerance. Evidence also suggests that rebaudioside I may possess both anti-inflammatory and anti-tumor properties, making it a promising candidate for therapeutic applications.
Rebaudioside D is extracted from the leaves of Stevia rebaudiana Bertoni. It is a potential sweetener. It showed similar stability when exposed to simulated stomach and small intestine fluids, with susceptibility to hydrolytic degradation by enteric bacteria collected from the cecum.
Rebastinib is an orally bioactive inhibitor of Bcr-Abl that binds to and inhibits Bcr-Abl fusion oncoprotein. Rebastinib changes the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation. It also exhibits inhibitory activity at SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2.
An impurity of Rebamipide. Rebamipide is an amino acid derivative of 2-(1H)-quinolinone. It can be used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis.
Raxatrigine is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker. It is a peripherally and centrally acting agent that inhibits sodium channels in a state-dependent fashion. It shows selectivity for the Nav1.7 subtype over the other subtypes tested for both the resting and depolarized states. It was developed by Convergence Pharmaceuticals. It received orphan-drug designation from the US Food and Drug Administration in July 2013. It is currently in phase II studies in bipolar depression.
Ranitidine EP Impurity J is an impurity of Ranitidine. Ranitidine is a medication that decreases stomach acid production. It can be used in treatment of peptic ulcer disease.
R-Amlodipine is an impurity of Amlodipine. Amlodipine is a long-acting dihydropyridine L-type calcium channel blocker. Amlodipine is used to lower blood pressure and prevent chest pain.
Ramipril is a second generation angiotensin-converting enzyme (ACE) inhibitor that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. It is used in treatment of congestive heart failure, hypertension and heart attacks. It is also useful in preventing renal and retinal complications in diabetes. It was developed by Pfizer and has been listed.
Ramelteon Impurity F is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia).
Ramelteon Impurity E is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia).
Ramelteon Impurity D is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia).
Ramelteon Impurity 7 HCl is an impurity of Ramelteon. Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia).
Ramelteon is a potent and selective agonist at melatonin MT1/MT2 receptor. Ramelteon is a sleep agent medication used to treat sleeplessness (insomnia).
