Poly-L-arginine hydrochloride has been used:• as polyelectrolyte solution in the synthesis of biodegradable capsules• as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells• in assay for the determination of binding activity of C-reactive protein for polycationic ligands
Polygalasaponin XXXI is a triterpenoid compound found in the herbs of Polygala japonica Houtt. In vivo, Polygalasaponin XXXI exhibits inhibitory effect on proliferation of mouse adapted influenza virus A/PR/8/34 and cyclic AMP phosphodiesterase.
Poly(D,L-lactide-co-glycolide) is used for macromolecular therapeutic delivery. Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid can enhance the level of toxin-neutralizing antibodies.
Polmacoxib is a first-in-class NSAID drug candidate that acts as a dual inhibitor of COX-2 and carbonic anhydrase (CA). It exhibits superior safety for cardiovascular, renal, and gastrointestinal tissues due to its dual COX-2 and CA binding properties. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
Policosanol is a mixture of long-chain alcohols found in plant waxes. Policosanol supplement is used as a lipid-lowering agent and potential hypotensive agent. Nutritional supplement in health care products.
PNU-282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).
p-Nitrophenyl 2-Acetamido-2-deoxy-α-D-galactopyranoside is an essential compound in biomedicine. It is commonly utilized in the production of synthetic substrates for studying glycosidase enzymes. This compound is valuable in research concerning carbohydrate chemistry, specifically in the investigation of enzymes involved in breaking down glycosylation processes. It plays a crucial role in medicinal chemistry by aiding in the development of drugs targeting certain diseases related to carbohydrate processing and glycosylation disorders.
P-Menthane-3,8-diol, also called PARA-MENTHANE-3,8-DIOL, PMD, 1-(2-Hydroxy-4-methylcyclohexyl)-1-methylethanol,ect. Found in small quantities in the essential oil from the leaves of Corymbia citriodora, formerly known as Eucalyptus citriodora. It smells similar to menthol and has a cooling feel.Our product is from natural source.
PMA, extracted from seeds of Euphorbia lathyris L, is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC), including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
PLX-647 is PLX647 is a potent inhibitors of both FMS and KIT that show strong selectivity compared with other kinases. In the in vitro enzymatic assay, PLX647 inhibits FMS with IC50 = 0.028μM and KIT with IC50 = 0.016 μM. PLX647 represents a unique class of kinase inhibitors with unique dual FMS and KIT specificity.
PLX51107 is a potent and selective BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2). It blocks the interaction mediated by the four BET family proteins.
SC1 (Pluripotin) was identified in a cell-based chemical library screen for small molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo.
Plerixafor Impurity III is an impurity of Plerixafor, an immunostimulant indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with NHL and MM.
An impurity of Plerixafor which is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
Pleconaril is a capsid function inhibitor which targets a conserved hydrophobic pocket of a major viral capsid protein called VP-1. Pleconaril inhibits attachment and virus uncoating.
Platycodin D3 has anti-hepatitis C virus (HCV) activity. It can be used as an expectorant in a variety of lung inflammatory diseases and regulate the production and secretion of mucin in the airway. Platycodin D3 is a triterpenoid compound and an inhibitor of NF-κB.
Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases.
PKG drug G1 is an activator of protein kinase GIα (PKGIα). It induces vasodilation and blood pressure reduction through the C42 PKG Iα independent mechanism.
Pizotifen is a benzocycloheptene-based drug used for the treatment of recurrent migraine headaches. It acts as an antagonist of 5-HT2A and 5HT2C receptors.
An impurity in the synthesis of Pitavastatin, a HMG-CoA reductase inhibitor that lowers LDL cholesterol and triglycerides and increase HDL cholesterol in your blood.
Pirenzepine hydrochloride is an antiulcerative that acts via suppressing gastric secretion. Pirenzepine is a selective muscarinic M1 receptor antagonist.
Piperoxan is an antihistamine drug which is derived from benzodioxan. At first it was investigated by Fourneau as an α-adrenergic-blocking agent, then they found it resistant to histamine-induced bronchospasm in guinea pigs.
