P7C3 is a proneurogenic and neuroprotective agent that activates NAMPT. P7C3 protects neurons from apoptosis and promotes neurogenesis in mice. It also improves cognitive function and memory in aged mice.
P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. In an in vivo orthotopic NB mouse model, P22077 significantly inhibited the xenograft growth of three NB cell lines. USP7-specific inhibitors like P22077 may serve not only as a stand-alone therapy but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact USP7-HDM2-p53 axis.
Ozenoxacin is a novel topical antibacterial agent in the class of quinolone. Its 1% topical cream is approved for the treatment of impetigo in Canada and US.
Ozanimod is a medication used for the treatment of multiple sclerosis (MS) and inflammatory bowel disease (IBD), specifically ulcerative colitis. Ozanimod is a selective sphingosine 1-phosphate (S1P) receptor modulator. It binds to S1P receptors on lymphocytes (a type of white blood cell), thereby inhibiting their egress from lymph nodes. This action reduces the number of circulating lymphocytes that can cause inflammation in the central nervous system (in the case of MS) or the intestines (in the case of ulcerative colitis). Ozanimod is indicated for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is also approved for the treatment of moderate to severe ulcerative colitis in adults who have not responded adequately to conventional therapies.
Oxytetracycline EP Impurity C is an impurity of Oxytetracycline, which is a broad-spectrum tetracycline antibiotic used for the treatment of various infectious diseases, like anthrax, Chlamydia, cholera, typhus, relapsing fever, malaria, plaque, syphilis, respiratory infection, streptococcal infection, and acne.
A derivative of Resveratrol. Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.
Oxyresveratrol 2-O-β-D-glucopyranoside is a derivative of Resveratrol. Resveratrol is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.
Oxypeucedanin, a derivative of coumarin of natural origins, has exhibited encouraging outcomes in the management of diverse medical conditions. Its potential as a cure for inflammatory diseases like arthritis is attributed to its anti-inflammatory characteristics. Moreover, oxypeucedanin has demonstrated anticancer features, particularly in the care for breast cancer. Its capacity for inducing apoptosis and hindering tumor growth elevates it as a propitious therapeutic alternative.
Oxyntomodulin is a naturally peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. Oxyntomodulin acts as a glucagon-like peptide 1 (GLP-1) receptor agonist.
Oxybuprocaine hydrochloride reversibly blocks sodium channels, which can be potentially used in ophthalmology and otolaryngology as a local anesthetic.
Oxocrebanine is an anti-breast cancer active aporphine alkaloid found in S. hainanensis. Oxocrebanine is a Topo I/IIα dual inhibitor, catalytic inhibitor and DNA intercalator.
Oxiran-2-ylmethyl 2-ethyl-2,5-dimethylhexanoate, a chemical compound with potential pharmaceutical applications, requires further research to fully understand its medical potential.
OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity.
Oxfendazole is the sulfoxide form of fenbendazole which is a broad spectrum benzimidazole anthelmintic. It can be used to control nematode disease and tapeworm disease in livestock.
Oxaliplatin is a platinum-based antineoplastic agent used in cancer chemotherapy that inhibits DNA synthesis by conforming DNA adducts in cancer cells.
OTX015 is a potent BET bromodomian inhibitor, which targets the BET bromodomain proteins 2, 3, and 4 (BRD). BRDs 2, 3, and 4 are considered potential cancer targets because of their pivotal role in regulating the transcription of growth-promoting genes and cell cycle regulators.
OTSSP167 is a potent inhibitor of Maternal embryonic leucine zipper kinase (MELK) which regulates neural stem cell selfrenewal through control of the cell cycle.
OTS-964, a thienoquinolin derivative, is a TOPK inhibitor and prabably be useful in studying anticancer agent as an analogue of OTS-514. It is still under preclinical trial. IC50: 28 nM.
The hydrochloride of OTS514. OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor (IC50 = 2.6 nM), with an inhibitory effect on small cell lung cancer (SCLC). It acts through suppressing growth of SCLC cell lines and inducing their apoptotic cell death.
o-Toluenesulfonic acid functions as a vital catalyst and acidic promoter frequently applied in the synthesis of organic compounds. Such a component is especially prevalent in the pharmaceutical sector owing to its ability to yield antihistamines, antitumor agents, and antibiotics. This reagent is an indispensable tool in advancing new medicines and treatments for a range of medical conditions and ailments.
OSU 03012 is an orally available, targeted anti-cancer agent that has been shown in pre-clinical studies to inhibit PDK-1, a protein in the PI3K/Akt pathway that is involved in the growth and proliferation of cells, including cancer cells. OSU 03012 may also cause cell death through the induction of stress in the endoplasmic reticulum.
OSI-930 is a selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers.
Oseltamivir EP Impurity C is the active metabolite of oseltamivir. Oseltamivir, also called as GS 4071 or Ro 64-0802, is an antiviral drug that competitively inhibits neuraminidase A and B (IC50 = 0.1 to 4.9 nM).
Oseltamivir Biotin conjugate 1 is a novel conjunction used for the targeted delivery of Oseltamivir, a drug for treating influenza caused by H1N1 and H3N2 strains. With the addition of Biotin, this conjugate provides selective binding to cells expressing biotin receptors, enhancing drug efficiency and reducing off-target effects.
ORY-1001 is a lysine specific demethylase 1 inhibitor under the development of Oryzon with IC50 value < 20nM. It selectively inhibits related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B > 100uM, SMOX 7uM). ORY-1001 can induce apoptosis in THP-1 and inhibit proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM). In THP-1 (MLL-AF9) cells, ORY-1001 results in a time-dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers.
ORM-15341, an androgen receptor antagonist, have potential effect against prostate cancer and is commonly found as an active main metabolite of ODM-201. IC50 = 38 nM.
Orientin, found in the herbs of Polygonum orientale Linn, exerts antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. Besides, Orientin may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.
Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity.
Orforglipron is a non-peptide, oral glucagon-like peptide-1 recceptor agonist (GLP-1RA). Orforglipron is a partial agonist, biased toward G protein activation over β-arrestin recruitment at the GLP-1R.
Orantinib is a multiple receptor tyrosine kinase inhibitor with IC50s of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively. It has greatest potency against PDGFR autophosphorylation.
ONO-AE3-208 is an EP4 antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively), which less potently affects EP3, FP, and TP receptors.
ONO-7475 is an Axl/Mer inhibitor that has been shown to inhibit the phosphorylation of AXL and Mer, and to suppress the growth of acute myeloid leukemia with FLT3 mutations (26, 27) and solid tumors.
