Procyanidin B1 is a procyanidin dimer found in Cinnamomum verum, in Uncaria guianensis, and in Vitis vinifera or in peach. Procyanidin B1 (PB1) inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with 50% effective concentrations of 29 and 15 μM, respectively. No inhibitory effects were observed in each component of PB1. PB1 does not interfere with viral entry or receptor expression, but inhibits HCV RNA synthesis in a dose-dependent manner.
Probucol Disuccinate is the succinate ester form of probucol, which is a potent oxidant. Probucol inhibits the oxidantion of cholesterol in LDLs, and also lowers HDL in patients with heart disease. Probucol is used as an anti-hyperlipidemic drug.
Presatovir is a viral fusion protein inhibitor with EC50 value of 0.43 nM. It can inhibit a broad range of respiratory syncytial virus clinical isolates by blocking the virus-cell fusion process. It can also inhibit pre- to post-fusion conformational changes of the respiratory syncytial virus fusion protein. Phase II clinical trials for the treatment of respiratory syncytial virus infections is ongoing.
An impurity of Prednisone. Prednisone is a synthetic corticosteroid drug. It can be used for the treatment of certain inflammatory diseases, some autoimmune diseases, and (at higher doses) some types of cancer.
pre-Alfacalcidol PTAD Adduct is an impurity of alfacalcidol, which is one of the synthetic analog of Vitamin D3 being effective in mediating intestinal calcium absorbtion and bone calcium metabolism.
PRE-084 Hydrochloride is a selective sigma-1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). PRE-084 is selective for PCP receptors (IC50 > 100000 nM) and several other receptor systems. It exhibits neuroprotective property.
A metabolite of Prasugrel. Prasugrel is a platelet inhibitor and an irreversible antagonist of P2Y12ADP receptors that prevents the formation of blood clots. It was appoved for the treatment of acute coronary syndrome (ACS), and some cardiovascular diseasess in combination with Aspirin.
Pramipexole is a dopamine agonist with Ki values of 3.9, 2.2, 0.5, 5.1 nM for D2S, D2L, D3 and D4 receptors respectively. It has been used for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS).
Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors.
PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 μM for p110α, p110β, p110δ, p110γ and DNA-PK, respectively.
PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM).
Potassium stearate is the potassium salt of stearic acid, mainly used as an emulsifier in the production of detergents, food, cosmetics and other consumer products. Potassium stearate has lubricating properties and helps prevent the separation of emulsions into oil and liquid components.
Alkoxymethyltrifluoroborate undergoes palladium-catalyzed carbon-carbon bond formation (Suzuki-Miyuara reaction) with aryl chlorides to provide a non-traditional disconnection for the preparation of aryl- and heteroaryl ethers.
Posaconazole Impurity 33 Oxalate is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme.
Posaconazole Diastereoisomer Related Compound 5 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme.
Posaconazole Diastereoisomer Related Compound 2 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme.
Posaconazole Diastereoisomer Related Compound 1 is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme.
Posaconazole Diastereoisomer 1 (R,R,R,R) is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme.
Posaconazole Diastereoisomer (S,R,S,S) is an impurity of Posaconazole. Posaconazole is a broad-spectrum triazole compound that is active against fungi by inhibiting the lanosterol 14α-demethylase enzyme.
POPC is phosphatidylcholine, a diacylglycerol and phospholipid. Its full name is 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine. BOC Sciences provides high-quality POPC for your projects.
Ponatinib hydrochloride is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). It is a multi-targeted tyrosine-kinase inhibitor. It has potential antiangiogenic and antineoplastic activities. It inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. It inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). It was developed by Ariad Pharm and has been listed.
Ponatinib is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
Pomalidomide-PEG5-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carboxylic acid for reactivity with an amine on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.
Pomalidomide-PEG3-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate containing a cereblon ligand based on Pomalidomide and a PEG linker of 3 O(CH2)2 units with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand.
Pomalidomide-PEG1-azide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal azide for click chemistry with a target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.
