Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated. These findings demonstrate that the coordinated inhibition of cell cycle progression and tyrosine kinase signaling by the multi-selective purvalanol A is effective in suppressing cancer progression associated with c-Src up-regulation.
Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cell:IC50= ~ 1.5 μM ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.
Punicalin is an ellagitannin. It is a highly active carbonic anhydrase inhibitor with strong antioxidative activity. Punicalin have anti-hepatotoxic activity but the larger dose of punicalin induced liver damage.
Punicalagin is an ellagitannin, a type of phenolic compounds. It had a greater antifungal activity against T. rubrum. It has the potential to be developed as an alternative or supplemental agent for prevention of Salmonella infection. After being absorbed by the human body, punicalagin can be decomposed into ellagic acid under the action of human enzymes. It has excellent antioxidant properties and has been used as a food antioxidant. It is now mostly used in cosmetics.
Pulsatilla saponin D, isolated from the root of Pulsatilla koreana, has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer. It effectively inhibited the growth of gastric cancer cells. It also strongly suppressed the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) and colon cancer cells and induced their apoptosis. Besides, it showed anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF.
Pulchinenoside B is an extract derived from a distinct plant, acting as a remarkable natural compound widely recognized in the field of diverse ailments research.
It acts as an HRP chemiluminescence enhancer. In the configuration of chemiluminescence substrate A/B solution, the addition of a certain amount of enhancer is helpful to enhance the luminescence intensity and sensitivity.
p-tert-Butoxycarbonyloxystyrene, an important monomer within the biomedical industry, is utilized in the synthesis of copolymers such as poly(styrene-alt-maleic anhydride). Due to its compatibility with therapeutic drugs, these copolymers are currently under investigation as potential therapies for a range of ailments, from cancer to inflammatory disorders.
p-Terphenyl-4-carboxylic acid has been employed as a reagent in the synthesis of diverse compounds, including p-terphenyl-3-carboxylic acid and p-terphenyl-2-carboxylic acid.
PTC-209 is a potent BMI-1 inhibitor with potential anticancer activity. PTC-209 inhibits endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells.
PT-2385 is a small molecule inhibitor with oral activity that inhibits hypoxia inducible factor (HIF)-2alpha heterodimerization and its subsequent binding to DNA by binding to HIF-2alpha.
PSI-7976 is an inhibitor of HCV RNA replication with EC50 value of 1.07μM. PSI-7851 is a phosphoramidate prodrug of PSI-7411 and has potent anti-hepatitis C virus (HCV) activity. It is a mixture of two diastereoisomers. PSI-7976 is one of them. Another one is PSI-7977. PSI-7851 is firstly activated through being hydrolyzed by CatA and CES1in the liver cells. It is found that CatA prefers PSI-7977 as a substrate over PSI-7976 while CES1 preferentially hydrolyzes PSI-7976 over PSI-7977. Since CES1 does not express in clone A replicon cells, the ability of PSI-7976 and PSI-7977 to inhibit HCV RNA replication is different in these cells. PSI-7977 is more potent than PSI-7976 with EC50 value of 92nM.
A metabolic process has been acknowledged for pseudoUridine, and it involves the pseudoUridine phosphorylation to generate pseudoUridine 5ʹ-monophosphate (ΨMP) catalyzed by the enzyme pseudoUridine kinase and thereafter the C-C glycosidic bond cleavage to give uracil and ribose 5-phosphate which mediated by the pseudoUridine 5ʹ-monophosphate glycosidase.
Pseudoginsenoside-RT5 is extracted from the roots of Panax ginseng C. A. Mey. It has antibacterial, antitumor and anti malaria effects. It promotes nerve growth and improves cognitive ability.
Pseudoginsenoside Rh2, a ginseng-derived natural compound, has garnered significant attention for its potential anti-cancer properties against breast and liver cancers. Beyond its anti-cancer benefits, it also demonstrates significant neuroprotective effects, which prove promising for the treatment of neurodegenerative diseases like Alzheimer’s and Parkinson’s. Its diverse applications in medicine suggest a broad range of future therapeutic opportunities.
A derivative of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction.
A metabolite of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction.
PRT062607, also known as PRT2607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. PRT062607 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL. Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with PRT062607 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations. PRT062607 may be a therapeutic agent for B-cell malignancies. A dose finding study in healthy volunteers has been completed.
Protoneogracillin is a furostanol glycoside that has anti-fungal activity against the plant pathogenic fungus P. oryzae (MMDC = 94.0 μM) and cytotoxic activity on K562 cancer cells (IC50 = 6.6 μM).
Protein hydrolyzates, yeast is a hydrolyzed product of yeast cells, which is obtained by autolysis or hydrolysis with additional enzymes. Hydrolyzed yeast products contain a large number of amino acids, small peptides, rich B vitamins, glutathione and nucleotide substances. It is mainly used as an antioxidant in cosmetics and skin care products, controlling oil and resisting fat overflow.
Prostaglandin-E1 is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It can be used as a vasodilator agent increasing peripheral blood flow.
The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deterioration of renal function and sorts of other diseases.
Prontosil is one of the earliest antimicrobial drugs that was widely used in mid-20th century. It has an effect against gram-positive cocci but not against enterobacteria.
An impurity of Progesterone.Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
An impurity of Progesterone.Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
An impurity of Progesterone.Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
An impurity of Progesterone. Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
Progesterone is a natural steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
