1075705-01-9

1075705-01-9 - Names and Identifiers

Name	4-Fluoro-2-methoxy-5-nitroaniline
Synonyms	AZD9291 intermediates uoro-2-methoxy-5-nitroaniL 4-Fluoro-2-methoxy-5-nitroaniline 4-fluoro-2-Methoxy-5-nitroaniline 4-Fluoro-2-Methoxy-5-nitrobenzenaMine 4-fluoro-2-methoxy-5-nitrophenylamine Benzenamine, 4-fluoro-2-methoxy-5-nitro- 2-Amino-5-fluoro-4-nitroanisole, 4-Fluoro-5-nitro-o-anisidine
CAS	1075705-01-9
EINECS	806-172-0

1075705-01-9 - Physico-chemical Properties

Molecular Formula	C7H7FN2O3
Molar Mass	186.14
Density	1.412±0.06 g/cm3(Predicted)
Melting Point	130 °C
Boling Point	354.8±37.0 °C(Predicted)
Appearance	powder to crystal
Color	Light yellow to Brown
pKa	2.31±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Use	This product is for scientific research only and shall not be used for other purposes.

1075705-01-9 - Reference Information

Use

4-fluoro-2-methoxy-5-nitroaniline is a reagent for the preparation of the anticancer drug Mereletinib.
4-fluoro-2-methoxy-5-nitroaniline is a reagent used for the preparation of an anticancer drug, melotinib.

preparation

4-fluoro-2-methoxyaniline (20g) was dissolved in concentrated sulfuric acid at -15 °c, all the solid in the mixture was dissolved, and a potassium nitrate solution (5.91g) dissolved in concentrated sulfuric acid was slowly added. Stirring was continued for 2H at this temperature. The reaction solution was poured into ice water, NaOH was added, pH was adjusted to 8.0-9.0, and the solid was precipitated by vigorous stirring and Suction filtration, 4-fluoro-2-methoxy-5-nitroaniline (22.0g) was obtained as a yellow solid in 83.7% yield.

Last Update：2024-04-10 22:29:15