367-12-4
2-Fluorophenol
CAS: 367-12-4
Molecular Formula: C6H5FO
367-12-4 - Names and Identifiers
| Name | 2-Fluorophenol |
| Synonyms | 2-Florophenol 2-fluoro-pheno 2-Fluorophenol 2-FLUOROPHENOL 2-Hydroxyfluorobenzene 2-FLUOROHYDROXYBENZENE Adjacent fluorine phenol 1-Fluoro-2-hydroxybenzene Fluorophenolmincolorlessliq |
| CAS | 367-12-4 |
| EINECS | 206-681-2 |
| InChI | InChI=1/C6H5FO/c7-5-3-1-2-4-6(5)8/h1-4,8H |
| InChIKey | HFHFGHLXUCOHLN-UHFFFAOYSA-N |
367-12-4 - Physico-chemical Properties
| Molecular Formula | C6H5FO |
| Molar Mass | 112.1 |
| Density | 1.256 g/mL at 25 °C (lit.) |
| Melting Point | 16.1 °C (lit.) |
| Boling Point | 171-172 °C/741 mmHg (lit.) |
| Flash Point | 116°F |
| Water Solubility | 80.72g/L(25 ºC) |
| Solubility | 37.7g/l |
| Vapor Presure | 2.86mmHg at 25°C |
| Appearance | Transparent liquid |
| Specific Gravity | 1.256 |
| Color | Clear colorless to light yellow-brownish |
| BRN | 1905112 |
| pKa | 8.73(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.511(lit.) |
| MDL | MFCD00002155 |
| Physical and Chemical Properties | Colorless transparent liquid, melting point 16.1 ℃, boiling point 171-172 ℃/741mmHg, Flash Point 46 ℃, specific gravity 1.256, refractive index 1.5140. |
| Use | Used as pesticide, pharmaceutical and dye intermediates |
367-12-4 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R10 - Flammable R63 - Possible risk of harm to the unborn child R43 - May cause sensitization by skin contact R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R45 - May cause cancer R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. S23 - Do not breathe vapour. S53 - Avoid exposure - obtain special instructions before use. S36 - Wear suitable protective clothing. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | SL4530000 |
| TSCA | T |
| HS Code | 29081000 |
| Hazard Note | Flammable/Corrosive |
| Hazard Class | 3 |
| Packing Group | III |
367-12-4 - Upstream Downstream Industry
367-12-4 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | 2-fluorophenol is a phenol derivative. Phenol is an important basic organic raw material, and many of its downstream products involve many fields, mainly used in the manufacture of phenolic resin, bisphenol A and caprolactam. Phenol derivatives such as halogenated phenols, nitrophenols, and alkylphenols can be used in the production of medicines, pesticides, paints, dyes, explosives, and spices. Phenol compounds are widely found in nature. Flavors and many natural products contain phenol structures. is an important intermediate of pharmaceutical and agricultural chemicals, used to synthesize fungicides, herbicides, and can also synthesize dye liquid crystals, plastics and rubber additives. Used as intermediate of pesticide, medicine and dye |
| preparation | add 1mmol phenol to 4ml of 10% acetic acid aqueous solution, add 1.5 mmolSelectfluor,0.05mmol Eosin Y to it, and react with 12W blue light at room temperature for 6 hours. after the reaction is over, add saturated NaCl aqueous solution to the reaction solution, extract with dichloromethane, and take the organic layer through anhydrous sodium sulfate drying, filtration, evaporation and drying, the crude compound is obtained. The crude compound was put into silica gel column chromatography, and the liquid with a volume ratio of ethyl acetate and petroleum ether of 1:9 was used as the mobile phase. TLC tracked and collected the eluent with an Rf value of 0.3-0.5. The collected eluent was reduced to remove the solvent and dried to obtain 2-fluorophenol 90mg (yield 77%). |
Last Update：2024-04-09 20:48:19
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Raw Materials for 367-12-4