A-ASARONE
alpha-Asarone
CAS: 2883-98-9
Molecular Formula: C12H16O3
A-ASARONE - Names and Identifiers
| Name | alpha-Asarone |
| Synonyms | ASARONE A-ASARONE ASARONE, A- alpha-Asaron ALPHA-ASARONE alpha-Asarion alpha-Asarone ALPHA-ASARONE (PHENOL DERIVATIVE) (e)-1,2,4-trimethoxy-5-(1-propenyl)benzene |
| CAS | 2883-98-9 |
| EINECS | 220-743-6 |
| InChI | InChI=1/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3/b6-5+ |
A-ASARONE - Physico-chemical Properties
| Molecular Formula | C12H16O3 |
| Molar Mass | 208.257 |
| Density | 1.028g/cm3 |
| Melting Point | 57-61℃ |
| Boling Point | 296°C at 760 mmHg |
| Flash Point | 107.7°C |
| Solubility | Soluble in ethanol, ether, glacial acetic acid, carbon tetrachloride, chloroform and petroleum ether, almost insoluble in water. |
| Vapor Presure | 0.0026mmHg at 25°C |
| Appearance | morphology neat |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.526 |
| MDL | MFCD00064457 |
| Physical and Chemical Properties | Melting point 57-61°C boiling point 296°C |
| Use | Use of this product has Cough, expectorant, Antiasthmatic, spasmolytic, sedative, antiepileptic, hypolipidemic, lipid-lowering and other effects on Pneumonia Diplococcus, the growth of Staphylococcus aureus and Escherichia coli have different degrees of inhibition, and have certain anticancer activity. |
A-ASARONE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24 - Avoid contact with skin. S25 - Avoid contact with eyes. |
| WGK Germany | 3 |
| RTECS | DC2975000 |
| HS Code | 29093090 |
A-ASARONE - Upstream Downstream Industry
| Raw Materials | BETA-ASARONE Ethyltriphenylphosphonium bromide 2,4,5-TRIMETHOXYLPRORIOPHENONE 2,4,5-Trimethoxybenzaldehyde |
A-ASARONE - Reference
| Reference Show more | 1. Yuan Siyuan, Wang Xiaohui, Sun Jiangyan, Liu Jinmin. Effects of α-asarone on expression of P-glycoprotein and multidrug resistance gene in brain tissue of drug-resistant epilepsy model rats [J]. Journal of Integrated Traditional Chinese and Western medicine, cardiovascular and cerebrovascular diseases 2019 17(21):3322-3325. 2. Liu Chongchong, Sun Jiangyan, Yuan Siyuan, Dong Xiaoke, Li Zhonghao, Wang Kaiyue, Liu Jinmin. Effects of chaibei Zhixian decoction and α-asarone on expression of P-gp and content of carbamazepine in brain of rats with intractable epilepsy [J]. Chinese Journal of Traditional Chinese Medicine, 2020,35(03):1203-1206. 3. Chen Ying, Yu Pengxin, Ding Hui, Jing Yao Yao, Zhang Lijuan, Yu river water, Yang Jianhui, Song Xinbo, Li Zheng. Study on the content changes of nine index components under the condition of different temperature and high pressure steam sterilization of the classic prescription Kaixin powder [J]. Chinese herbal medicine, 2021,52(04):976-981. 4. [IF = 4.821] Wei Wei et al.Effective separation of alpha-asarone and beta-asarone in TCM by covalent organic framework modified by magnetic solid phase extraction.Microchem J. 2021 Nov;:107015 |
A-ASARONE - Nature
| solubility | Soluble in chloroform, methanol. |
| sensitivity | Light Sensitive |
| maximum wavelength (& lambda;max) | 312nm(EtOH)(lit.) |
| BRN | 1910606 |
| NIST chemical information | Asarone(2883-98-9) |
Last Update：2024-04-09 19:04:55
A-ASARONE - Uses and synthesis methods
overview
α-asarone, alias asarone, α-asarone, Asarone. Chemical name: 2,4, 5-trimethoxy-1-propylbenzene, is the main active ingredient of the traditional Chinese medicine Acorus calamus (AcorigramineiRhizoma). It has sedative, anticonvulsant, antiasthmatic, expectorant, antitussive, antispasmodic, choleretic and other effects, and has different degrees of inhibition on the growth of pneumococcus, Staphylococcus aureus and Escherichia coli. The extracted monomers have received good results in clinical application to pneumonia, asthma, grand epileptic seizures, etc.
physical and chemical properties
soluble in ethanol, ethyl acetate, ether and chloroform, insoluble in water. The melting point of its yellowish crystal state is 59~60 ℃; the melting point of needle crystal state is 62~63 ℃, and the boiling point is 296 ℃.
application
1. Epilepsy
2. Chronic obstructive pulmonary disease (COPD)
3. Hyperlipidemia
dose and usage
oral administration: 2 tablets each time, 3 tablets for severe cases, 3 times a day; 5~14 years old, l tablets to 1 and a half tablets each time, 3~4 times a day; 1~4 years old, half tablets to 1 tablet each time, 3 times a day.
precautions
few adverse reactions, no toxic adverse reactions to heart, liver and kidney. Use with caution for patients with severe liver and kidney dysfunction. Only slight dry mouth, dizziness, nausea, stomach discomfort, palpitation and constipation at the initial stage of taking the medicine, can disappear by itself without stopping the medicine.
Last Update：2024-04-09 21:04:16
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View History
Raw Materials for A-ASARONE
BETA-ASARONE
Ethyltriphenylphosphonium bromide
2,4,5-TRIMETHOXYLPRORIOPHENONE
2,4,5-Trimethoxybenzaldehyde
Ethyltriphenylphosphonium bromide
2,4,5-TRIMETHOXYLPRORIOPHENONE
2,4,5-Trimethoxybenzaldehyde