Poly(D-lactide)COOH

Poly(D-lactide)COOH - Names and Identifiers

Name	Poly(D-lactide)COOH
Synonyms	OH-PDLA-COOH Poly(D-lactide)COOH

Poly(D-lactide)COOH - Physico-chemical Properties

Appearance	Crystalline polymer, white to light yellow irregular particles or powder
Storage Condition	-20℃

Poly(D-lactide)COOH - Introduction

Poly(D-lactide)COOH(Poly(D-lactide)COOH) is a dextrorotatory poly lactic acid polymer with terminal carboxyl functional groups. Its properties include the following:

1. structural characteristics: the basic unit of Poly(D-lactide)COOH is D-lactic acid, which forms a linear polymer chain by acid catalyst polymerization, and introduces carboxyl functional groups at the end of the chain.

2. physical properties: Poly(D-lactide)COOH is a colorless or yellow powder solid. It has a high melting point and melt viscosity, and can be melted into a flowing state within a certain temperature range.

3. chemical properties: Poly(D-lactide)COOH is soluble in some organic solvents (such as chloroform, benzene, etc.), and insoluble in water. It can react with other functional compounds, such as amine compounds to form amide bonds.

Poly(D-lactide)COOH has a wide range of applications in the field of medicine:

1. Biodegradable materials: As a biodegradable polymer, Poly(D-lactide)COOH can be used to prepare sutures, bone repair materials, etc. Its biodegradable nature allows it to be gradually broken down and metabolized, reducing the burden on the human body.

2. Drug delivery: Poly(D-lactide)COOH can be used as a drug carrier, wrapping the drug inside the polymer to control the release rate of the drug, prolong the residence time of the drug in the body, and improve the therapeutic effect.

3. Tissue engineering: Poly(D-lactide)COOH is used in tissue engineering research and can be used as a scaffold material for artificial tissues to provide support for cell growth.

Poly(D-lactide)COOH can be prepared by the following steps:

1. Acid-catalyzed polymerization: D-lactic acid monomer is used and cyclic polymerization is carried out by an acid catalyst (such as hydrochloric acid) to generate dextrorotatory polylactic acid.

2. terminal carboxylation: the carboxyl functional group is introduced into the end of polylactic acid, and the compound (such as γ-hydroxybutyric acid) that can react with the carboxyl group can undergo transesterification reaction to introduce the carboxyl group into the end of the polylactic acid chain.

In terms of safety information, Poly(D-lactide)COOH is a biodegradable material and is safe in most cases. However, note the following:

1. Avoid direct contact with skin and eyes during operation to avoid irritation or allergic reactions.

2. during use, please follow the relevant safety operation procedures and personal protective measures.

3. if ingested or inhaled by mistake, please seek medical advice or medical attention immediately.

In general, Poly(D-lactide)COOH, as a biodegradable polymer, has a wide range of applications in medicine and tissue engineering. In the process of use, it is necessary to follow the relevant safety operation guidelines to ensure safe use.

Last Update：2024-04-09 20:11:46