SPIROBIINDANE

Name	SPIROBIINDANE
Synonyms	SPIROBIINDANE 3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-6,6'-diol 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro[1,1'-spirobi[1H-indene]]-6,6'-diol 2,2'',3,3''-TETRAHYDRO-3,3,3'',3''-TETRAMETHYL-1,1''-SPIROBI-1H-INDENE- 6,6''-DIOL
CAS	1568-80-5

Molecular Formula	C21H24O2
Molar Mass	308.41
Density	1.21±0.1 g/cm3(Predicted)
Melting Point	213-214 °C
Boling Point	478.5±45.0 °C(Predicted)
pKa	9.98±0.60(Predicted)
Storage Condition	2-8℃
In vitro study	HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn 2+ as the cationic cofactor by gel assay with IC 50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC 50 value of 200 µM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC 50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD 50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.

biological activity	HIV-1 integrase inhibitor 8 is a HIV-1 integrase (HIV-1 integrase) inhibitor, compound 8.
in vitro study	HIV-1 integrase inhibitor 8 is against 3 '-processing (TC) and strand-transfer (ST) activities in the presence of Mn 2 + as the cationic cofactor by gel assay with IC 50 values of 275 m and 200 m, respectively. It inhibits the strand-transfer (ST) activity with an IC 50 value of 200 µM. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter say. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC 50 values of 500 m and 200 m, respectively. this result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD 50 (pose at which the signal is reduced 50% due to cell death) of 20 μ m in HeLa cells.
EPA chemical information	information provided by: ofmpub.epa.gov (external link)

Last Update：2024-04-09 21:04:16

Product Name: SPIROBIINDANE Visit Supplier Webpage Request for quotation
CAS: 1568-80-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: SPIROBIINDANE Visit Supplier Webpage Request for quotation
CAS: 1568-80-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

SPIROBIINDANE

SPIROBIINDANE Request for Quotation