mPEG-MAL

mPEG-MAL - Names and Identifiers

Name	mPEG-MAL
Synonyms	mPEG-MAL PEG-MALEIMIDE METHOXYPOLYETHYLENE GLYCOL 5,000 MALEIMIDE O-(2-MALEIMIDOETHYL)-O'-METHYLPOLYETHYLENE GLYCOL 5'000 MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER MONO-METHYL POLYETHYLENE GLYCOL 5,000 2-MALEIMIDO-ETHYL ETHER
CAS	99126-64-4

mPEG-MAL - Physico-chemical Properties

Molecular Formula	(C2H4O)n.C7H9NO3
Melting Point	48-52 °C
Flash Point	>110 °C
Storage Condition	-20°C

mPEG-MAL - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
FLUKA BRAND F CODES	3-10-23
HS Code	39072090

mPEG-MAL - Reference Information

Overview

with the rapid development of biotechnology, more and more protein and peptide drugs have been applied in the prevention and treatment of diseases. Although the action site of protein polypeptide drugs is specific and the curative effect is exact, but the low solubility, poor stability, short half-life, immunogenicity and other defects limit their route of administration and efficacy. Polyethylene glycol (PEG) modification can solve the above problems.

Application

in the sulfhydryl site-directed modification of protein and peptide drugs, the activated PEG used more frequently was maleimidyl polyethylene glycol monomethyl ether (mPEG-MAL). To avoid cross-linking and agglomeration during the modification process, a single methoxy polyethylene glycol (mPEG-OH) is usually used as the raw material for the synthesis of the modifying agent.

Last Update：2024-04-09 21:01:54