叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯

叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯 - Names and Identifiers

Name	tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate
Synonyms	BOC-N-(2-HYDROXYETHYL)PIPERAZINE 1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE 1-(TERT-BUTOXYCARBONYL)-4-(2-HYDROXYETHYL)PIPERAZINE tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate 4-(2-HYDROXYETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-(2-HYDROXYETHYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE 4-(2-HYDROXYETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER [4-(2-hydroxyethyl)-1-[(2-methylpropan-2-yl)oxy]-2-piperazinylidene]methanone
CAS	77279-24-4

叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯 - Physico-chemical Properties

Molecular Formula	C11H22N2O3
Molar Mass	230.3
Density	1.092±0.06 g/cm3(Predicted)
Melting Point	38-42 °C
Boling Point	114°C 0,1mm
Flash Point	110°C
Appearance	Solid
Color	White to pale brown
pKa	14.96±0.10(Predicted)
Storage Condition	2-8°C

叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
Hazard Note	Irritant
Hazard Class	6.1
Packing Group	Ⅲ

叔丁基-4-(2-羟乙基)哌嗪-1-羧酸酯 - Introduction

tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate, the chemical formula is C13H26N2O3, is an organic compound.

Nature:
-Appearance: Colorless or light yellow liquid or solid.
-Solubility: Soluble in organic solvents such as alcohols, ethers and chlorinated hydrocarbons.
-Melting point: about 30-40 degrees Celsius.
-Stability: Stable at room temperature.

Use:
- tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate can be used as a synthetic drug intermediate for the preparation of many drugs, such as antipsychotics, antidepressants and antiemetic drugs.

Preparation Method:
The preparation method of tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate can be obtained by the following steps:
1. First, tert-butyl chloroformate is reacted with 2-hydroxyethyl piperazine to generate tert-butyl -4-(2-hydroxyethyl) piperazine.
2. Then, in the presence of a base, it reacts with chloroformic acid to generate the tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate.

Safety Information:
- tert-Butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate is an organic compound and will not directly cause harm to the human body under normal circumstances.
-During use, it is recommended to follow chemical safety practices, such as wearing protective gloves, glasses and laboratory coats.
-In case of swallowing or skin contact, flush with plenty of water and seek medical help.

Last Update：2024-04-09 21:01:54