Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride MedChemExpress (MCE)

Product Name	α-toluenesulphonyl fluoride
Synonyms	PMSF Phenylmethanesulfony BENZYLSULFONYL FLUORIDE A-TOLUENESULFONYL FLUORIDE A-TOLUENESULPHONYL FLUORIDE α-toluenesulphonyl fluoride P-TOLUENESULPHONYL FLUORIDE Synonyms PMSF Phenylmethanesulfony BENZYLSULFONYL FLUORIDE A-TOLUENESULFONYL FLUORIDE A-TOLUENESULPHONYL FLUORIDE α-toluenesulphonyl fluoride P-TOLUENESULPHONYL FLUORIDE Phenylmethansulfonylfluorid α-toluenesulphonyl fluoride Phenylmethanesulfonyl fluoride benzenemethanesulfonyl fluoride BENZENEMETHANESULFONYL FLUORIDE 2-methylbenzenesulfonyl fluoride .alpha.-Toluenesulfonyl fluoride Fluorure de phénylméthanesulfonyle Phenylmethanesulfonyl fluoride,α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride
CAS	329-98-6
EINECS	206-350-2
Chemical Formula	C7H7FO2S
Molecular Weight	174.19
inchi	InChI=1/C7H7FO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3
Package	10 mM * 1 mL;25 mg;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	PMSF PMSF MedChemExpress (MCE) HY-B0496 329-98-6 Phenylmethylsulfonyl fluoride Descriptions PMSF PMSF MedChemExpress (MCE) HY-B0496 329-98-6 Phenylmethylsulfonyl fluoride Benzylsulfonyl fluoride 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. PMSF (2 mM) inhibits carbachol-stimulated inositol phosphate accumulation in the presence of Li+ by only 15%-19%. PMSF inhibition of phosphoinositide turnover is due to one or more steps following phosphoinositide breakdown[1]. PMSF inhibits the acylation of the inositol residue of GPI intermediates in bloodstream-form T. brucei. PMSF inhibits the formation of glycolipid C but does not inhibit fatty acid remodeling in vitro. PMSF inhibits GPI acylation and ethanolamine phosphate addition in procyclic trypanosomes but not in Hela cells[2]. PMSF (0.1 mL/10 g b.wt, i.p.) produces antinociception as indicated by the dose-responsive increase in % MPE in the tail-flick latency evaluation, but fails to produce a clear dose-responsive inhibition of locomotion. Mice receiving i.p. injections of PMSF exhibit cannabinoid effects that includes antinociception, hypothermia and immobility with ED50 values of 86, 224 and 206 mg/kg, respectively. PMSF (30 mg/kg) pretreatment potentiates the effects of anandamide on tail-flick response (antinociception), spontaneous activity and mobility by 5-, 10- and 8-fold, respectively[3]. Male ICR mice weighing 18 to 25 g are used in the assay. PMSF is dissolved in sesame oil and administered i.p. at a volume of 0.1 mL/10 g b.wt. PMSF is always administered 10 min before i.v. anandamide or vehicle injections. Mice are acclimated to the evaluation room overnight without interruption of food or water. After i.v. anandamide or vehicle administration each animal is evaluated as follows: tail-flick latency (antinociception) response at 5 min and spontaneous (locomotor) activity at 5 to 15 min or core (rectal) temperature at 5 min and ring-immobility (catalepsy) at 5 to 10 min. \| \| \| \| \| \| \| \| \| \| [1]. Sekar, M.C. and B.D. Roufogalis, Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum. Cell Calcium, 1984. 5(3): p. [Content Brief] [2]. Guther, M.L., W.J. Masterson, and M.A. Ferguson, The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes. J Biol Chem, 1994. 269(28): p. 18694-701. [Content Brief] [3]. Compton, D.R. and B.R. Martin, The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J Pharmacol Exp Ther, 1997. 283(3): p. 1138-43. [Content Brief]
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Last Update	2025-05-21 16:50:25

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