CP 76136-27 MedChemExpress (MCE)

Product Name	Danofloxacin mesylate
Synonyms	Advoci Nofloxacin CP-76136-27 DANOFLOXACIN MESILATE Danofloxacin mesylate DANOFLOXACIN MESYLATE DANOFLOXACIN MESULATE Synonyms Advoci Nofloxacin CP-76136-27 DANOFLOXACIN MESILATE Danofloxacin mesylate DANOFLOXACIN MESYLATE DANOFLOXACIN MESULATE DANOFLOXANCIN MESYLATE Mesylate Dan Nuosha star 1-cyclopropyl-6-fluoro-7-[(1s,4s)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid monomethanesulfonate
CAS	119478-55-6
EINECS	638-813-3
Chemical Formula	C20H24FN3O6S
Molecular Weight	453.48
inchi	InChI=1/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1
Package	10 mM * 1 mL;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Danofloxacin mesylate Danofloxacin mesylate MedChemExpress (MCE) HY-B0501 119478-55-6 CP 76136-27 99.87% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Danofloxacin mesylate Danofloxacin mesylate MedChemExpress (MCE) HY-B0501 119478-55-6 CP 76136-27 99.87% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2). Danofloxacin mesylate (1-25 μM 1 h) transport across Caco-2 cells is asymmetric, with a rate of secretion exceeding that of absorption[1]. Danofloxacin mesylate (18 h) inhibits bovine bacterial respiratory pathogens with the MIC90 of 0.06-0.125 μg/mL for Pasteurella hemolyticus, Pasteurella multocida and Haemophilus somnosus[2]. Pharmacokinetic Analysis in geese[3] Route Dose (mg/kg) (Non-salt dose) AUC(0-t) (μg·h/mL) AUC(0-inf) (μg·h/mL) kel (1/h) ka (1/h) k10 (1/h) k21 (1/h) k12 (1/h) t1/2kel (h) Cmax (μg/mL) Tmax (h) Cl (mL/g·h) V1 (mL/g) V2 (mL/g) F % i.v. 5 14.27 15.35 0.10 / 0.25 1.14 1.34 6.61 / / 0.35 1.46 1.71 / p.o. 5 8.30 9.14 0.17 0.32 / / / 4.12 0.96 1.70 / / / 57.95 \| \| \| \| \| \| \| \| \| \| [1]. Schrickx JA, et al. Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters. Br J Pharmacol. 2007 Feb 150(4):463-9. [Content Brief] [2]. Giles, C.J., et al., Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J Vet Pharmacol Ther, 1991. 14(4): p. 400-10. [Content Brief] [3]. Sartini I, et al. Danofloxacin pharmacokinetics and tissue residues in Bilgorajska geese. Res Vet Sci. 2021 May 136:11-17. [Content Brief]
Last Update	2025-04-01 14:45:47

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