PNU-282987 MedChemExpress (MCE)

Product Name	N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE
Synonyms	CS-1012 PNU 282987 PNU-282987 PNU282987 HCl PNU 282987(PNU 282987 hydrochloride) N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride Synonyms CS-1012 PNU 282987 PNU-282987 PNU282987 HCl PNU 282987(PNU 282987 hydrochloride) N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride PNU 282987
CAS	123464-89-1
EINECS
Chemical Formula	C14H17ClN2O
Molecular Weight	264.75058
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	PNU-282987 PNU-282987 MedChemExpress (MCE) HY-12560A 123464-89-1 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year Descriptions PNU-282987 PNU-282987 MedChemExpress (MCE) HY-12560A 123464-89-1 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 1 year -20°C, 6 months (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems. PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM[1]. PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM[1]. PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM[1]. PNU-282987 (Compound C7) (i.v. 1, 3 mg/kg) leads to a reversal of the gating deficit[1]. PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1]. IC50: 4541nM (5-HT3) EC50: 154 nM (α7 nAChR) Ki: 27 nM (R7 MLA)[1] In Vitro PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM[1]. PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM[1]. PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PNU-282987 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Alice L Bodnar, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem [Content Brief]
Supplier Website	https://www.medchemexpress.com/PNU-282987.html
Last Update	2025-05-21 16:50:25

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