BAY 11-7821 MedChemExpress (MCE)

Product Name	BAY 11-7082
Synonyms	100824;CS-608;BAY 11-7821;BAY 11-7082;Bay 11-7821(BAY 11-7082);(E)-3-(P-TOLUENESULFONYL)ACRYLONITRILE;(e)-3-(4-methylphenyl)sulfonylprop-2-enenitrile;(E)-3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE
CAS	19542-67-7
EINECS
Chemical Formula	C10H9NO2S
Molecular Weight	207.25
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	BAY 11-7082 BAY 11-7082 MedChemExpress (MCE) HY-13453 19542-67-7 BAY 11-7821 99.98% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions BAY 11-7082 BAY 11-7082 MedChemExpress (MCE) HY-13453 19542-67-7 BAY 11-7821 99.98% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. BAY 11-7082 (BAY 11-7821), an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line[1]. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A[2]. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ[3]. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules[4]. BAY 11-7082 (2.5 mg/kg and 5 mg/kg intratumoral injection twice-weekly for 21 days) significantly suppresses tumor growth in a dose-dependent manner[6]. NF-κB USP7 0.19 μM (IC50) USP21 0.96 μM (IC50) Autophagy \| \| \| \| \| \| \| \| \| \| [1]. Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines andprimary adult T-cell leukemia cells. Blood. 2002 Sep 1 100(5):1828-1834. [Content Brief] [2]. Ritorto MS, et al. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun. 2014 Aug 27 5:4763. [Content Brief] [3]. Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1 451(3):427-437. [Content Brief] [4]. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22 272(34):21096-103. [Content Brief] [5]. Jun Jacob Hu, et al. Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D. The Preprint Server For Biology, 2018,Jul. 10. [6]. Chen L , et al. BAY 11-7082, a nuclear factor-κB inhibitor, induces apoptosis and S phase arrest in gastriccancer cells. J Gastroenterol. 2014 May 49(5):864-74. [Content Brief]
Last Update	2025-04-01 14:45:47

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