MK-1439 MedChemExpress (MCE)

Product Name	Doravirine
Synonyms	MK-1439 Doravirine MK-1439(Doravirine) 3-chloro-5-[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile 3-chloro-5-((1-((4-Methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)Methyl)-2-oxo-4-(trifluoroMethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile Synonyms MK-1439 Doravirine MK-1439(Doravirine) 3-chloro-5-[1-[(4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)pyridin-3-yl]oxybenzonitrile 3-chloro-5-((1-((4-Methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)Methyl)-2-oxo-4-(trifluoroMethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile 3-Chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]benzonitrile Benzonitrile, 3-chloro-5-[[1-[(4,5-dihydro-4-methyl-5-oxo-1H-1,2,4-triazol-3-yl)methyl]-1,2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]-
CAS	1338225-97-0
EINECS
Chemical Formula	C17H11ClF3N5O3
Molecular Weight	425.75
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Doravirine Doravirine MedChemExpress (MCE) HY-16767 1338225-97-0 MK-1439 99.79% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Doravirine Doravirine MedChemExpress (MCE) HY-16767 1338225-97-0 MK-1439 99.79% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Doravirine (MK-1439) is a highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50s of 4.5 nM, 5.5 nM and 6.1 nM against the wild type and K103N and Y181C reverse transcriptase mutants, respectively. Selectivity and cytotoxicity studies confirmed that Doravirine is a highly specific nonnucleoside reverse transcriptase inhibitors with minimum off-target activities. In the presence of 50% normal human serum (NHS), Doravirine shows excellent potency in suppressing the replication of WT virus, with a 95% effective concentration (EC95) of 20 nM, as well as K103N, Y181C, and K103N/Y181C mutant viruses with EC9595 of 43, 27, and 55 nM, respectively. Doravirine exhibits similar antiviral activities against 10 different HIV-1 subtype viruses (a total of 93 viruses)[1]. Administration of 50 mg Doravirine with a high-fat meal is associated with slight elevations in AUC time zero to infinity and C24 h with no change in Cmax[2]. IC50: 4.5 nM (wild type reverse transcriptase) 5.5 nM ( K103N reverse transcriptase) 6.1 nM (Y181C reverse transcriptase)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Lai MT et al. In vitro characterization of MK-1439, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2014 58(3):1652-63. [Content Brief] [2]. Anderson MS et al. Safety, tolerability and pharmacokinetics of doravirine, a novel HIV non-nucleoside reverse transcriptase inhibitor, after single and multiple doses in healthy subjects. Antivir Ther. 2015 20(4):397-405. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Doravirine.html
Last Update	2025-05-21 16:50:25

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