RF9 MedChemExpress (MCE)

Product Name	2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
Synonyms	RD9 RF 9 RF9 trifluoroacetate salt 1-Adamantanecarbonyl-Arg-Phe-NH2 2-Adamantanecarbonyl-Arg-Phe-NH2 2-ADAMANTANECARBONYL-ARG-PHE-NH2 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE Synonyms RD9 RF 9 RF9 trifluoroacetate salt 1-Adamantanecarbonyl-Arg-Phe-NH2 2-Adamantanecarbonyl-Arg-Phe-NH2 2-ADAMANTANECARBONYL-ARG-PHE-NH2 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE 1-Adamantanecarbonyl-Arg-Phe-NH2 trifluoroacetate salt L-Phenylalaninamide, N2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-L-arginyl-
CAS	876310-60-0
EINECS
Chemical Formula	C26H38N6O3
Molecular Weight	482.62
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	RF9 RF9 MedChemExpress (MCE) HY-107382 876310-60-0 98.14% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions RF9 RF9 MedChemExpress (MCE) HY-107382 876310-60-0 98.14% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively. RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells[2]. RF9 (0.1 mg/kg, s.c.) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[1]. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1]. hNPFF1R 58 nM (Ki) hNPFF2R 75 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10 103(2):466-71. [Content Brief] [2]. Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15 27(4):630-643. [Content Brief]
Last Update	2025-04-01 14:45:47

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