TSH-888 MedChemExpress (MCE)

Product Name	Pyributicarb
Synonyms	tsh-888 henyl)ester PYRIBUTYCARB Pyributicarb PYRIBUTICARB O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate n-(6-methoxy-2-pyridyl)-n-methyl-thiocarbamicacio-3-tert-butylphenyleste Synonyms tsh-888 henyl)ester PYRIBUTYCARB Pyributicarb PYRIBUTICARB O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate n-(6-methoxy-2-pyridyl)-n-methyl-thiocarbamicacio-3-tert-butylphenyleste carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(3-(1,1-dimethylethyl)p n-(6-methoxy-2-pyridyl)-n-methylthiocarbamic acid o-3-tert-butylphenyl ester
CAS	88678-67-5
EINECS
Chemical Formula	C18H22N2O2S
Molecular Weight	330.44
inchi
Package	25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Pyributicarb Pyributicarb MedChemExpress (MCE) HY-111202 88678-67-5 TSH-888 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Pyributicarb Pyributicarb MedChemExpress (MCE) HY-111202 88678-67-5 TSH-888 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells[1]. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF)[2]. Pyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1]. Male ICR mice (5 weeks old) are used and fed standard rodent chow. After 18-h fasting, mice are injected i.v. with adenovirus [4.0 ×109 50% titer culture infectious dose (TCID50)/mouse]. Three days after the infection, vehicle (0.5% methyl cellulose/saline) or Pyributicarb (100 mg/kg/day) is administered p.o. for 2 consecutive days. Animals are killed 20 h after the last dose[1]. HepG2-derived cells stably expressing the CYP3A4 reporter gene (3-1-10 cells) are used in this experiment. The cells are treated with 0.3 to 30 μM Pyributicarb for 48 h. Then reporter activities are determined[1]. CYP3A4[1], hPXR[2] In Vitro Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells[1]. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF)[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Pyributicarb Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Matsubara T, et al. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos. 2007 May 35(5):728-33. [Content Brief] [2]. Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27 280(3):77-87. [Content Brief]
Last Update	2025-04-01 14:45:47

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