AA 861 MedChemExpress (MCE)

Product Name	docebenone
Synonyms	AA-861 AA 861 A 61589 Decebenone Docebenona Docebenone docebenone Synonyms AA-861 AA 861 A 61589 Decebenone Docebenona Docebenone docebenone Docebenonum UNII-2XRX3BD53M AA-861(Docebenone) Docebenonum [INN-Latin] Docebenona [INN-Spanish] 2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p-benzoquinone 2-[12-HYDROXYDODECA-5,10-DIYNYL]-3,5,6-TRIMETHYL-P-BENZOQUINONE 2-(12-Hydroxydodecane-5,10-diynyl)-3,5,6-trimethyl-p-benzoquinone 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione 2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione 2,5-Cyclohexadiene-1,4-dione, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl- 2-(12-hydroxydodeca-5,10-diyn-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione
CAS	80809-81-0
EINECS
Chemical Formula	C21H26O3
Molecular Weight	326.43
inchi	InChI=1/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h22H,5,7-10,12,14-15H2,1-3H3
Package	10 mM * 1 mL;1 mg;5 mg
Price	Email to quote
Descriptions	Docebenone Docebenone MedChemExpress (MCE) HY-12886 80809-81-0 AA 861 99.31% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Docebenone Docebenone MedChemExpress (MCE) HY-12886 80809-81-0 AA 861 99.31% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production[1]. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently[2]. Docebenone might protect experimental acute necrotizing pancreatitis in rats[3]. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M[4]. Rats[3] Pancreatitis is induced in rats by retrograde injection of 0.4 mL/kg body wt of 6% taurocholic acid into the pancreatic duct. The animals are divided into three groups: control group administered Docebenone in a single dose of 30 mg/kg and administered Docebenone in a single dose of 60 mg/kg. The following parameters are examined: serum amylase, lipase, trypsin, blood sugar, and survival rate[3]. 5-LO \| \| \| \| \| \| \| \| \| \| [1]. Nam YH, et al. Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. Inflamm Res. 2012 Feb 61(2):97-102. [Content Brief] [2]. Huang JK, et al. AA-861-induced Ca(2+) mobilization in Madin Darby canine kidney cells. Toxicol Appl Pharmacol. 1999 Dec 1 161(2):202-8. [Content Brief] [3]. Kiriyama M, et al. Protective effect of AA-861 (5-lipoxygenase inhibitor) on experimental acute necrotizing pancreatitis in rats. Int J Pancreatol. 1993 Jun 13(3):201-8. [Content Brief] [4]. Yamamura H, et al. Effect of AA-861, a selective 5-lipoxygenase inhibitor, on models of allergy in several species. Jpn J Pharmacol. 1988 Jul 47(3):261-71. [Content Brief]
Last Update	2025-04-01 14:45:47

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