80809-81-0
docebenone
CAS: 80809-81-0
Molecular Formula: C21H26O3
80809-81-0 - Names and Identifiers
80809-81-0 - Physico-chemical Properties
| Molecular Formula | C21H26O3 |
| Molar Mass | 326.43 |
| Density | 1.071g/cm3 |
| Boling Point | 488.5°C at 760 mmHg |
| Flash Point | 263.3°C |
| Solubility | ethanol: |
| Vapor Presure | 1.36E-11mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.532 |
| In vitro study | Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB 4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca 2+ ] i concentration dependently. |
| In vivo study | Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10 -8 -10 -5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10 -8 -10 -5 M. |
80809-81-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
80809-81-0 - Reference Information
| biological activity | Docebenone (AA 861) is a potent, selective and orally active 5-lipoxygenase (5-LO) inhibitors. |
Last Update：2024-04-09 15:16:53
